Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jan 22:2020:8121659.
doi: 10.1155/2020/8121659. eCollection 2020.

Single Nucleotide Polymorphisms in IFN- γ Signaling Pathway Associated with Risk of Hepatitis B Virus Infection in Chinese Children

Yang Zhuo  1 , Yalan Yang  1 , Mingjun Zhang  2 , Ying Xu  1 , Zhongping Chen  2 , Lihong Mu  1 , Xiaojun Tang  1 , Zhaohui Zhong  1 , Juan Chen  3 , Li Zhou  1
Affiliations

Single Nucleotide Polymorphisms in IFN- γ Signaling Pathway Associated with Risk of Hepatitis B Virus Infection in Chinese Children

Yang Zhuo et al. Can J Infect Dis Med Microbiol. .

Abstract

Hepatitis B virus (HBV) infection is a challenging public health problem in China and worldwide. Mother-to-child transmission is one of the main transmission routes of HBV in highly endemic regions. However, the mechanisms of HBV perinatal transmission in children have not been clearly defined. The aim of this study was to demonstrate the association between single-nucleotide polymorphisms (SNPs) in IFN-γ signaling pathway and HBV infection or breakthrough infection in children. Two hundred and seventy-four HBV-infected children defined as test positive for hepatitis B surface antigen (HBsAg) and 353 controls defined as negative for HBsAg in China were recruited from October 2013 to May 2015. SNPs in IFN-γ signaling pathway including IFNG, IFNGR1, IFNGR2, and IL12B were genotyped. Rs2234711 in IFNGR1 was significantly associated with HBV infection in children (OR = 0.641, 95% CI: 0.450-0.913). In addition, rs2234711 was also significantly associated with HBV breakthrough infection in children born to HBsAg-positive mothers (OR = 0.452, 95% CI: 0.205-0.998). Our study confirmed that genetic variants in IFN-γ signaling pathway have significant associations with HBV infection, especially with HBV breakthrough in children. This study provides insight into HBV infection in children and could be used to help design effective strategies for reducing immunoprophylaxis failure.

PubMed Disclaimer

Conflict of interest statement

The authors do not have any conflicts of interest in the study.

Similar articles

See all similar articles

Cited by

References

    1. Liaw Y.-F., Chu C.-M. Hepatitis B virus infection. The Lancet. 2009;373(9663):582–592. doi: 10.1016/s0140-6736(09)60207-5. - DOI - PubMed
    1. World Health Organization. Hepatitis B. World Health Organization Fact Sheet. Geneva, Switzerland: WHO; 2017. http://www.who.int/mediacentre/factsheets/fs204/en/index.html.
    1. Komatsu H., Inui A. Hepatitis B virus infection in children. Expert Review of Anti-infective Therapy. 2015;13(4):427–450. - PubMed
    1. Russo F. P., Rodriguez C. K., Scribano L., Gottardo G., Vanin V., Farinati F. Role of antiviral therapy in the natural history of hepatitis B virus-related chronic liver disease. World Journal of Hepatology. 2015;7(8):1097–1104. doi: 10.4254/wjh.v7.i8.1097. - DOI - PMC - PubMed
    1. Poovorawan Y., Chongsrisawat V., Theamboonlers A., et al. Long-term benefit of hepatitis B vaccination among children in Thailand with transient hepatitis B virus infection who were born to hepatitis B surface antigen-positive mothers. The Journal of Infectious Diseases. 2009;200(1):33–38. doi: 10.1086/599331. - DOI - PubMed