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. 2019 Dec 24;6(1):e516.
doi: 10.1097/TXD.0000000000000960. eCollection 2020 Jan.

Tacrolimus-Induced Optic Neuropathy After Multivisceral Transplantation

Emilio Canovai  1   2 , Catherine Cassiman  3 , Laurens J Ceulemans  1   2 , Philippe Demaerel  4 , Mauricio Sainz-Barriga  1   2 , Ina Jochmans  1   2 , Diethard Monbaliu  1   2 , Jacques Pirenne  1   2 , Tim Vanuytsel  1   5
Affiliations

Tacrolimus-Induced Optic Neuropathy After Multivisceral Transplantation

Emilio Canovai et al. Transplant Direct. .
No abstract available

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1.
FIGURE 1.
Pattern visual evoked potential (pVEP). A, At time of vision loss showing bilateral severely diminished amplitude in responses. B, One year after treatment: complete recovery.
FIGURE 2.
FIGURE 2.
Magnetic resonance imaging (MRI) of the brain. A, At time of vision loss showing severe a thickened optic chiasm (asterisk) and high signal in both optic tracts (arrows). B, One year after treatment: complete recovery.
FIGURE 3.
FIGURE 3.
Timeline of case, including implemented treatment. CS, corticosteroids; IVIG, intravenous immunoglobulin; MVTx, multivisceral transplant.
See this image and copyright information in PMC

References

    1. van Sandwijk MS, Bemelman FJ, Ten Berge IJ. Immunosuppressive drugs after solid organ transplantation. Neth J Med. 2013;71:281–289. - PubMed
    1. Berger M, Zeevi A, Farmer DG, et al. Immunologic challenges in small bowel transplantation. Am J Transplant. 2012;12(Suppl 4):S2–S8. - PubMed
    1. DiMartini A, Fontes P, Dew MA, et al. Age, model for end-stage liver disease score, and organ functioning predict posttransplant tacrolimus neurotoxicity. Liver Transpl. 2008;14:815–822. - PMC - PubMed
    1. Zivković SA, Abdel-Hamid H. Neurologic manifestations of transplant complications. Neurol Clin. 2010;28:235–251. - PubMed
    1. Venneti S, Moss HE, Levin MH, et al. Asymmetric bilateral demyelinating optic neuropathy from tacrolimus toxicity. J Neurol Sci. 2011;301:112–115. - PubMed