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Review
. 2020 May;42(5):1067-1076.
doi: 10.1002/hed.26104. Epub 2020 Feb 12.

Prognostic value of epithelial-mesenchymal transition-inducing transcription factors in head and neck squamous cell carcinoma: A meta-analysis

Yuehan Wan  1   2 , Haichao Liu  1   2 , Ming Zhang  1   2 , Zhengxian Huang  1   2 , Han Zhou  1   2 , Yue Zhu  1   2 , Yifan Tao  2 , Nan Xie  2   3 , Xiqiang Liu  1   2 , Jinsong Hou  1   2 , Cheng Wang  1   2
Affiliations
Review

Prognostic value of epithelial-mesenchymal transition-inducing transcription factors in head and neck squamous cell carcinoma: A meta-analysis

Yuehan Wan et al. Head Neck. 2020 May.

Abstract

Epithelial-mesenchymal transition (EMT) plays a critical role in cancer progression and is primarily regulated by several EMT-inducing transcription factors (EMT-TFs), including TWIST1, TWIST2, SNAI1, SNAI2, ZEB1, and ZEB2. However, the prognostic value of EMT-TFs remains controversial in head and neck squamous cell carcinoma (HNSCC). Studies on the prognostic role of EMT-TFs in HNSCC were searched for in the Web of Science, Science Direct, Proquest, EMBASE, PubMed, and Cochrane Library. Meta-analysis was performed by using Revman 5.2 software. The pooled analysis showed that overexpression of EMT-TFs indicated a poor overall survival (OS) (HR = 1.93, 95% CI = 1.67-2.23) of HNSCC. Subgroup analysis for individual EMT-TFs revealed that overexpression of TWIST1 (HR = 1.61, 95% CI = 1.29-2.02), SNAI1 (HR = 2.17, 95% CI = 1.63-2.88), SNAI2 (HR = 1.90, 95% CI = 1.38-2.62), and ZEB1 (HR = 2.70, 95% CI = 1.61-4.53) were significantly associated with poor OS of HNSCC. These findings support the hypothesis that overexpression of EMT-TFs indicates a poor prognosis for HNSCC patients.

Keywords: EMT-TFs; HNSCC; biomarkers; meta-analysis; prognosis.

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References

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