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Comment
. 2020 Feb 10;52(3):259-260.
doi: 10.1016/j.devcel.2020.01.020.

RREB1 Integrates TGF-β and RAS Signals to Drive EMT

Laurent Fattet  1 , Jing Yang  2
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Comment

RREB1 Integrates TGF-β and RAS Signals to Drive EMT

Laurent Fattet et al. Dev Cell. .
Free article

Abstract

TGF-β is long known to require Ras activation to induce EMT. In a recent issue of Nature, Massagué and colleagues (Su et al., 2020) identify RAS-responsive element binding protein 1 (RREB1) as a critical integrator of TGF-β and Ras signals during both developmental and cancer EMT programs.

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