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Comment
. 2020 Feb 10;37(2):145-146.
doi: 10.1016/j.ccell.2020.01.008.

Circles with a Point: New Insights into Oncogenic Extrachromosomal DNA

Christopher J Ott  1
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Circles with a Point: New Insights into Oncogenic Extrachromosomal DNA

Christopher J Ott. Cancer Cell. .
Free article

Abstract

For decades, scientists have observed small extrachromosomal DNA fragments in tumor cells, yet comprehensive examination of their structure and function has remained difficult. Three recent studies, published in Nature, Cell, and Nature Genetics, have now shed important light on the architecture, regulatory capacity, and oncogenic nature of tumor-associated extrachromosomal DNA.

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  • Functional Enhancers Shape Extrachromosomal Oncogene Amplifications.
    Morton AR, Dogan-Artun N, Faber ZJ, MacLeod G, Bartels CF, Piazza MS, Allan KC, Mack SC, Wang X, Gimple RC, Wu Q, Rubin BP, Shetty S, Angers S, Dirks PB, Sallari RC, Lupien M, Rich JN, Scacheri PC. Morton AR, et al. Cell. 2019 Nov 27;179(6):1330-1341.e13. doi: 10.1016/j.cell.2019.10.039. Epub 2019 Nov 21. Cell. 2019. PMID: 31761532 Free PMC article.

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