Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Mar;114(3):477-483.
doi: 10.36660/abc.20180377.

Factors Associated with Recurrence in Takotsubo Syndrome: A Systematic Review

[Article in English, Portuguese]
Felipe Alverenga Duarte Campos  1 , Luiz Eduardo Fonteles Ritt  1   2 , João Paulo Soares Costa  1 , Constança Margarida Cruz  1   3 , Gilson Soares Feitosa-Filho  1   4 , Queila Borges de Oliveira  2 , Eduardo Sahade Darzé  1   2
Affiliations

Factors Associated with Recurrence in Takotsubo Syndrome: A Systematic Review

[Article in English, Portuguese]
Felipe Alverenga Duarte Campos et al. Arq Bras Cardiol. 2020 Mar.

Abstract

Background: Takotsubo syndrome (TTS) is characterized by a temporary systolic dysfunction of the left ventricle (LV) related to a stressful event. However, the factors associated with its recurrence are still not well established.

Objective: To analyze the main factors associated with TTS recurrence.

Methods: A systematic review was performed using the PRISMA model. Observational studies, published between January 2008 and October 2017, which presented a recurrence rate of at least 3% and/or 5 or more patients with recurrence, and who met at least 80% of the STROBE criteria were included.

Results: six articles reached the criteria to compose this systematic review. The recurrence rate ranged from 1 to 3.5% per year (global recurrence rate 3.8%). One study associated higher recurrence rate with the female gender, four reported the time between the first and second episodes, one study associated body mass index (BMI) and hypercontractility of the LV middle anterior wall to a higher recurrence rate. No association between recurrence and electrocardiographic changes were determined. Beta-blockers use was not associated with recurrence rates.

Conclusions: Female gender, time from the first episode of the syndrome, low BMI and midventricular obstruction were reported as potential predictors of TTS recurrence.

PubMed Disclaimer

Conflict of interest statement

Potencial conflito de interesses

Declaro não haver conflito de interesses pertinentes.

Figures

Figura 1
Figura 1. Fluxograma Prisma da seleção dos estudos para a composição da revisão sistemática.
Figure 1
Figure 1. Prisma Flowchart of the studies selection for the composition of the systematic review.
See this image and copyright information in PMC

Comment in

  • Takotsubo Syndrome: A Recurrent Disease?
    Fernandes F, Montera MW. Fernandes F, et al. Arq Bras Cardiol. 2020 May-Jun;114(3):484-485. doi: 10.36660/abc.20200080. Arq Bras Cardiol. 2020. PMID: 32267318 Free PMC article. English, Portuguese. No abstract available.
  • Recurrent Takotsubo Cardiomyopathy: A Puzzle Yet to be Solved.
    Yalta K, Kaya C. Yalta K, et al. Arq Bras Cardiol. 2020 Sep;115(3):590-591. doi: 10.36660/abc.20200140. Arq Bras Cardiol. 2020. PMID: 33027387 Free PMC article. English, Portuguese. No abstract available.

References

    1. Lemos AET, Araújo AL, Junior, Lemos MT, Belém L de S, Vasconcelos FJC, Filho, Barros RB. Síndrome do coração partido (síndrome de Takotsubo) Arq Bras Cardiol. 2008;90(1):e1–e3. - PubMed
    2. 1. Lemos AET, Junior Araújo AL, Lemos MT, Belém L de S, Vasconcelos Filho FJC, Barros RB. Síndrome do coração partido (síndrome de Takotsubo). Arq Bras Cardiol. 2008;90(1):e1–3. - PubMed
    1. Lyon AR, Bossone E, Schneider B, Sechtem U, Citro R, Underwood SR, et al. Current state of knowledge on Takotsubo syndrome: a Position Statement from the Taskforce on Takotsubo Syndrome of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2016;18(1):8–27. - PubMed
    2. 2. Lyon AR, Bossone E, Schneider B, Sechtem U, Citro R, Underwood SR, et al. Current state of knowledge on Takotsubo syndrome: a Position Statement from the Taskforce on Takotsubo Syndrome of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2016;18(1):8–27. - PubMed
    1. Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Jaguszewski M, et al. Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy. N Engl J Med. 2015;373(10):929–938. - PubMed
    2. 3. Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Jaguszewski M, et al. Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy. N Engl J Med. 2015;373(10):929–38. - PubMed
    1. Parodi G, Citro R, Bellandi B, Del Pace S, Rigo F, Marrani M, et al. Tako-tsubo cardiomyopathy and coronary artery disease. Coron Artery Dis. 2013;24(6):527–533. - PubMed
    2. 4. Parodi G, Citro R, Bellandi B, Del Pace S, Rigo F, Marrani M, et al. Tako-tsubo cardiomyopathy and coronary artery disease. Coron Artery Dis. 2013;24(6):527–33. - PubMed
    1. Singh K, Parsaik A, Singh B. Recurrent takotsubo cardiomyopathy. Herz. 2014;39(8):963–967. - PubMed
    2. 5. Singh K, Parsaik A, Singh B. Recurrent takotsubo cardiomyopathy. Herz. 2014;39(8):963–7. - PubMed

Publication types