Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 May;13(5):e201960197.
doi: 10.1002/jbio.201960197. Epub 2020 Feb 23.

Label-free stimulated Raman scattering imaging reveals silicone breast implant material in tissue

Ludo van Haasterecht  1   2 , Liron Zada  1   3 , Robert W Schmidt  1 , Erik de Bakker  2   4 , Ellis Barbé  5 , Heather A Leslie  3 , A Dick Vethaak  3   6 , Susan Gibbs  4   7 , Johannes F de Boer  1 , Frank B Niessen  2 , Paul P M van Zuijlen  2   8 , Marie Louise Groot  1 , Freek Ariese  1
Affiliations

Label-free stimulated Raman scattering imaging reveals silicone breast implant material in tissue

Ludo van Haasterecht et al. J Biophotonics. 2020 May.

Abstract

Millions of women worldwide have silicone breast implants. It has been reported that implant failure occurs in approximately a tenth of patients within 10 years, and the consequences of dissemination of silicone debris are poorly understood. Currently, silicone detection in histopathological slides is based on morphological features as no specific immunohistochemical technique is available. Here, we show the feasibility and sensitivity of stimulated Raman scattering (SRS) imaging to specifically detect silicone material in stained histopathological slides, without additional sample treatment. Histology slides of four periprosthetic capsules from different implant types were obtained after explantation, as well as an enlarged axillary lymph node from a patient with a ruptured implant. SRS images coregistered with bright-field images revealed the distribution and quantity of silicone material in the tissue. Fast and high-resolution imaging of histology slides with molecular specificity using SRS provides an opportunity to investigate the role of silicone debris in the pathophysiology of implant-linked diseases.

Keywords: capsular contraction; label-free histology; nonlinear optics; pathology; plastic surgery; polymer detection; silicone bleeding.

PubMed Disclaimer

References

REFERENCES

    1. M. B. Calobrace, M. R. Schwartz, K. R. Zeidler, T. A. Pittman, R. Cohen, W. G. Stevens, Aesthetic Surg. J. 2018, 38(1), 38.
    1. The International Society of Aesthetic Plastic Surgery. (2017). Annual ISAPS International Survey on Aesthetic/Cosmetic Procedures in 2017.
    1. R. M. Kappel, A. J. H. Klunder, G. J. M. Pruijn, Eur. J. Plast. Surg. 2014, 37(3), 123.
    1. E. F. C. de Fleury, M. M. Rêgo, L. C. Ramalho, V. J. Ayres, R. O. Seleti, C. A. P. Ferreira, D. J. Roveda, Breast Cancer Targets Ther. 2017, 9, 133.
    1. R. Vaamonde, J. M. Cabrera, R. J. Vaamonde-Martín, I. Jimena, J. M. Martín, Histol. Histopathol. 1997, 12(4), 1003.

Publication types

LinkOut - more resources