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. 2020 Apr;22(4):633-638.
doi: 10.1111/jch.13829. Epub 2020 Feb 12.

Sodium restriction improves nocturia in patients at a cardiology clinic

Thomas F Monaghan  1 , Kyle P Michelson  1 , Zhan D Wu  1 , Fred Gong  1 , Christina W Agudelo  1 , Christopher D George  1 , Upeksha S Alwis  2 , Matthew R Epstein  1 , Pakinam Mekki  1 , Viktor X Flores  1 , Donald L Bliwise  3 , Karel Everaert  2 , Johan Vande Walle  4 , Jeffrey P Weiss  1 , Jason M Lazar  5
Affiliations

Sodium restriction improves nocturia in patients at a cardiology clinic

Thomas F Monaghan et al. J Clin Hypertens (Greenwich). 2020 Apr.

Abstract

This study aims to determine whether dietary sodium restriction counseling decreases nocturnal voiding frequency in cardiology patients with concomitant nocturia. Patients who had established care at a cardiology clinic from 2015 to 2018 reporting ≥1 average nocturnal void(s) underwent a comprehensive sodium intake interview by their cardiologist, who provided them with individualized strategies for dietary sodium reduction and assessed adherence at follow-up. Average nocturnal voiding frequency and dietary adherence were documented in the medical record. A nocturia database was compiled for retrospective analysis. A total of 74 patients were included. Patients considered to be adherent with dietary sodium restriction at follow-up (n = 56) demonstrated a decrease in median nocturia frequency (2.5 [2.3-3.0] vs 1.0 [1.0-2.0] voids, P < .001). Among nonadherent patients (n = 18), median nocturia frequency did not significantly change from baseline to follow-up (2.0 [1.5-3.8] vs 2.0 [1.5-4.8] voids, P = .423). Median changes were significantly different between the adherent and nonadherent groups (P < .001). Examination of second follow-up available from 37 patients showed a continued effect. In conclusion, adherence with dietary sodium counseling appears to improve nocturia. Accordingly, dietary modification may represent an important adjunct therapy to lifestyle and pharmacologic interventions for decreasing nocturia frequency. Reduction in nocturnal voiding frequency may also reflect an additional benefit of dietary sodium restriction in accordance with best practice standards for cardiovascular disease.

Keywords: LUTS; Urology; diet; salt.

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Conflict of interest statement

Thomas F. Monaghan has no direct or indirect commercial incentive associated with publishing this article and certifies that all conflicts of interest relevant to the subject matter discussed in the manuscript are the following: Dr Bliwise has served as a consultant for Merck, Jazz, Ferring, Eisai, and Respicardia and speaker for Merck within the last 3 years, outside the submitted work. Dr Everaert is a consultant and lecturer for Medtronic and Ferring and reports institutional grants from Allergan, Ferring, Astellas, and Medtronic, outside the submitted work. Dr Vande Walle reports institutional grants from Allergan, Astellas, and Ferring, and is a consultant and lecturer for Ferring and Astellas, outside the submitted work. Dr Weiss is a consultant for Ferring and the Institute for Bladder and Prostate Research, outside the submitted work. The other authors have nothing to disclose.

Figures

Figure 1
Figure 1
Self‐reported patient adherence to individualized dietary sodium counseling provided at the baseline encounter. Second follow‐up data were available for 37/74 (50%) patients included in the present analysis (29/56 [52%] of patients deemed adherent at first follow‐up and 8/18 [44%] of patients deemed nonadherent at first follow‐up were lost for second follow‐up)
Figure 2
Figure 2
Frequency distribution of change in number of nocturnal voids (calculated as second follow‐up minus baseline) for patients with two follow‐ups. Patients adherent to sodium‐restricted diet (at either first or second follow‐up) (n = 30) shown in black; nonadherent patients at both follow‐ups (n = 7) shown as cross‐hatched. Difference significant at P = .02
See this image and copyright information in PMC

Comment in

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