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. 2020 Feb 12;9(1):29.
doi: 10.1186/s13643-020-1273-4.

Prescription drug diversion, misuse, and abuse among people living with HIV: a scoping review protocol

Buyisile Chibi  1   2   3 , Neusa Fernanda Torres  4   5 , Tivani P Mashamba-Thompson  1   6
Affiliations

Prescription drug diversion, misuse, and abuse among people living with HIV: a scoping review protocol

Buyisile Chibi et al. Syst Rev. .

Abstract

Background: Prescription drugs are controlled medicines due to their potential risks of being diverted, misused, and abused. Since the introduction of antiretroviral (ARVs) drugs, HIV is currently regarded as a chronic condition. However, prescription drug diversion, misuse, and abuse might serve as one of the critical barriers for achieving optimal medication adherence among people living with HIV, thereby negatively impacting the HIV care mandate. The primary aim of this scoping review is to gather evidence on the prevalence, practices, risk factors, and motives associated with prescription drug diversion, misuse, and abuse, as well as the evidence on the association between prescription drug diversion, misuse, and abuse with antiretroviral treatment (ART) adherence.

Methods: This review will be guided by Arksey and O'Malley's framework as well as recommendations by Levac et al. (Implement Sci 5:69, 2010). We will search the following databases for relevant literature meeting our eligibility criteria: PubMed, Google Scholar, EBSCOhost (Academic Search Complete, MEDLINE, and Newspaper Source), World Health Organization, Science Direct, and Open Access Theses and Dissertations. Studies published within the period of January 1996 to June 2019 are eligible. The included studies should report evidence on the prevalence, practices, risk factors, motives, or association between ART adherence and prescription drug diversion, misuse, and abuse. Thematic analysis will be applied to summarize the review findings.

Discussion: We anticipate finding a considerable number of research studies on prescription drug diversion, misuse, and abuse among people living with HIV. Our synthesis of this evidence base is intended to serve as guidance for future research studies. The study findings will be disseminated through the traditional academic platforms, such as peer-reviewed publications and presentations at relevant local and international conferences, symposiums, and seminars.

Systematic review registration: PROSPERO CRD42017074076.

Keywords: Abuse; Adherence; Diversion; Drug; Misuse; People living with HIV; Prescription.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Study selection flowchart
See this image and copyright information in PMC

References

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