[Effect of hyperthermia and ionizing radiation separately or in combination on tumor metastasis]

Abstract

The paper is devoted to a study of the effect of hyperthermia and irradiation used alone or in combination on the frequency and intensity of metastasizing of Walker carcinoma in rats, sarcoma-37 and 2 types (LLC and LLC-1) of Lewis lung carcinoma in mice. The frequency and intensity of metastasis depend not only on tumor type but also on a transplantation site. Metastasizing of tumor cells transplanted under the leg skin, occurs after a tumor reaches the volume of 25 mm3. Local hyperthermia (40-45 degrees C) and irradiation used alone or in combination, do not change the frequency and intensity of metastasis. However if a rise of body temperature is noted in local hyperthermia, larger tumor nodes appear in the lungs without evidence of an increase in the number of metastases.