Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jun 29;222(2):252-262.
doi: 10.1093/infdis/jiaa069.

T Lymphocyte Subsets Associated With Prevalent Diabetes in Veterans With and Without Human Immunodeficiency Virus

Samuel S Bailin  1 , Kathleen A McGinnis  2 , Wyatt J McDonnell  1 , Kaku So-Armah  3 , Melissa Wellons  1 , Russell P Tracy  4 , Margaret F Doyle  4 , Simon Mallal  1 , Amy C Justice  2   5 , Matthew S Freiberg  1   6 , Alan L Landay  7 , Celestine Wanjalla  1 , John R Koethe  1   6
Affiliations

T Lymphocyte Subsets Associated With Prevalent Diabetes in Veterans With and Without Human Immunodeficiency Virus

Samuel S Bailin et al. J Infect Dis. .

Abstract

Background: A higher proportion of circulating memory CD4+ T cells is associated with prevalent diabetes mellitus in the general population. Given the broad changes in adaptive immunity, including memory T-cell expansion, and rising prevalence of diabetes in the human immunodeficiency virus (HIV) population, we assessed whether similar relationships were present in persons with HIV (PWH).

Methods: Multiple CD4+ and CD8+ T-cell subsets were measured by flow cytometry, and prevalent diabetes cases were adjudicated by 2 physicians for PWH and HIV-negative participants in the Veterans Aging Cohort Study. Multivariable logistic regression models evaluated the association of T-cell subsets and diabetes stratified by HIV status, adjusted for cytomegalovirus serostatus and traditional risk factors.

Results: Among 2385 participants (65% PWH, 95% male, 68% African American), higher CD45RO+ memory CD4+ T cells and lower CD38+ CD4+ T cells were associated with prevalent diabetes, and had a similar effect size, in both the PWH and HIV-negative (P ≤ .05 for all). Lower CD38+CD8+ T cells were also associated with diabetes in both groups.

Conclusions: The CD4+ and CD8+ T-cell subsets associated with diabetes are similar in PWH and HIV-negative individuals, suggesting that diabetes in PWH may be related to chronic immune activation.

Keywords: HIV; T lymphocytes; metabolic disease; systemic inflammation; type 2 diabetes mellitus.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
CD4+ T-cell subsets associated with prevalent diabetes in persons with human immunodeficiency virus (HIV) and HIV-negative individuals using multivariable logistic regression modeling adjusted for age, sex, body mass index, race, hepatitis C virus, and cytomegalovirus serostatus, smoking status, alcohol use, interleukin-6, D-dimer, and soluble CD14. Models for HIV+ also adjusted for plasma HIV-1 ribonucleic acid suppression (<500 copies/mL). T-cell percentage is plotted on the x-axis, and risk of prevalent diabetes is plotted on the y-axis. Error bars represent 95% confidence intervals.
Figure 2.
Figure 2.
CD8+ T-cell subsets associated with prevalent diabetes in persons with human immunodeficiency virus (HIV) and HIV-negative individuals using multivariable logistic regression modeling adjusted for age, sex, body mass index, race, hepatitis C virus, and cytomegalovirus serostatus, smoking status, alcohol use, interleukin-6, D-dimer, and soluble CD14. Models for HIV+ also adjusted for plasma HIV-1 ribonucleic acid suppression (<500 copies/mL). T-cell percentage is plotted on the x-axis and risk of prevalent diabetes is plotted on the y-axis. Error bars represent 95% confidence intervals.
See this image and copyright information in PMC

References

    1. Crum-Cianflone N, Roediger MP, Eberly L, et al. Increasing rates of obesity among HIV-infected persons during the HIV epidemic. PLoS One 2010; 5:e10106. - PMC - PubMed
    1. Brown TT, Cole SR, Li X, et al. Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the multicenter AIDS cohort study. Arch Intern Med 2005; 165:1179–84. - PubMed
    1. Taylor BS, Liang Y, Garduño LS, et al. High risk of obesity and weight gain for HIV-infected uninsured minorities. J Acquir Immune Defic Syndr 2014; 65:e33–40. - PMC - PubMed
    1. De Wit S, Sabin CA, Weber R, et al. Incidence and risk factors for new-onset diabetes in HIV-infected patients: the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study. Diabetes Care 2008; 31:1224–9. - PMC - PubMed
    1. Butt AA, McGinnis K, Rodriguez-Barradas MC, et al. HIV infection and the risk of diabetes mellitus. AIDS 2009; 23:1227–34. - PMC - PubMed

Publication types