Is nitric oxide the forgotten nephroprotective treatment during cardiac surgery?

doi:10.1186/s13613-020-0631-7

. 2020 Feb 12;10(1):22.

doi: 10.1186/s13613-020-0631-7.

Is nitric oxide the forgotten nephroprotective treatment during cardiac surgery?

Mina Khorashadi¹, Michael P Bokoch¹, Matthieu Legrand^{2

3}

Affiliations

¹ Department of Anesthesiology and Peri-Operative Medicine, University of California - UCSF Medical Center, 500 Parnassus Ave, San Francisco, CA, 94143, USA.
² Department of Anesthesiology and Peri-Operative Medicine, University of California - UCSF Medical Center, 500 Parnassus Ave, San Francisco, CA, 94143, USA. matthieu.legrand@ucsf.edu.
³ Institute National de la Santé et de la Recherche Médicale (INSERM) 942, Lariboisière Hospital & F-CRIN INI-CRCT, Paris, France. matthieu.legrand@ucsf.edu.

PMID: 32052208
PMCID: PMC7016086
DOI: 10.1186/s13613-020-0631-7

Is nitric oxide the forgotten nephroprotective treatment during cardiac surgery?

Mina Khorashadi et al. Ann Intensive Care. 2020.

. 2020 Feb 12;10(1):22.

doi: 10.1186/s13613-020-0631-7.

Authors

Mina Khorashadi¹, Michael P Bokoch¹, Matthieu Legrand^{2

3}

Affiliations

¹ Department of Anesthesiology and Peri-Operative Medicine, University of California - UCSF Medical Center, 500 Parnassus Ave, San Francisco, CA, 94143, USA.
² Department of Anesthesiology and Peri-Operative Medicine, University of California - UCSF Medical Center, 500 Parnassus Ave, San Francisco, CA, 94143, USA. matthieu.legrand@ucsf.edu.
³ Institute National de la Santé et de la Recherche Médicale (INSERM) 942, Lariboisière Hospital & F-CRIN INI-CRCT, Paris, France. matthieu.legrand@ucsf.edu.

PMID: 32052208
PMCID: PMC7016086
DOI: 10.1186/s13613-020-0631-7

No abstract available

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Conflict of interest statement

ML received research funding from the French ministry of health, research support from Sphingotec, lecture fees from Fresenius and Baxter and consulting fees from Novartis. The other authors declare that they have no competing of interests.

Figures

**Fig. 1**
Proposed mechanisms of renal protection using nitric oxide during cardiac surgery with cardio-pulmonary bypass. *Free Oxy-Hb* oxyhemoglobin, *Met-Hb* methemoglobin

See this image and copyright information in PMC

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References

1. Thiele RH, Isbell JM, Rosner MH. AKI associated with cardiac surgery. Clin J Am Soc Nephrol. 2015;10:500–514. doi: 10.2215/CJN.07830814. - DOI - PMC - PubMed
1. Vermeulen Windsant IC, de Wit NCJ, Sertorio JTC, van Bijnen AA, Ganushchak YM, Heijmans JH, et al. Hemolysis during cardiac surgery is associated with increased intravascular nitric oxide consumption and perioperative kidney and intestinal tissue damage. Front Physiol. 2014;5:340. doi: 10.3389/fphys.2014.00340. - DOI - PMC - PubMed
1. Legrand M, Mik EG, Johannes T, Payen D, Ince C. Renal hypoxia and dysoxia after reperfusion of the ischemic kidney. Mol Med. 2008;14:502–516. doi: 10.2119/2008-00006.Legrand. - DOI - PMC - PubMed
1. Lei C, Berra L, Rezoagli E, Yu B, Dong H, Yu S, et al. Nitric oxide decreases acute kidney injury and stage 3 chronic kidney disease after cardiac surgery. Am J Respir Crit Care Med. 2018;198:1279–1287. doi: 10.1164/rccm.201710-2150OC. - DOI - PMC - PubMed
1. Ruan S-Y, Huang T-M, Wu H-Y, Wu H-D, Yu C-J, Lai M-S. Inhaled nitric oxide therapy and risk of renal dysfunction: a systematic review and meta-analysis of randomized trials. Crit Care. 2015;19:137. doi: 10.1186/s13054-015-0880-2. - DOI - PMC - PubMed

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[1] Thiele RH, Isbell JM, Rosner MH. AKI associated with cardiac surgery. Clin J Am Soc Nephrol. 2015;10:500–514. doi: 10.2215/CJN.07830814. - DOI - PMC - PubMed

[2] Thiele RH, Isbell JM, Rosner MH. AKI associated with cardiac surgery. Clin J Am Soc Nephrol. 2015;10:500–514. doi: 10.2215/CJN.07830814. - DOI - PMC - PubMed

[3] Vermeulen Windsant IC, de Wit NCJ, Sertorio JTC, van Bijnen AA, Ganushchak YM, Heijmans JH, et al. Hemolysis during cardiac surgery is associated with increased intravascular nitric oxide consumption and perioperative kidney and intestinal tissue damage. Front Physiol. 2014;5:340. doi: 10.3389/fphys.2014.00340. - DOI - PMC - PubMed

[4] Vermeulen Windsant IC, de Wit NCJ, Sertorio JTC, van Bijnen AA, Ganushchak YM, Heijmans JH, et al. Hemolysis during cardiac surgery is associated with increased intravascular nitric oxide consumption and perioperative kidney and intestinal tissue damage. Front Physiol. 2014;5:340. doi: 10.3389/fphys.2014.00340. - DOI - PMC - PubMed

[5] Legrand M, Mik EG, Johannes T, Payen D, Ince C. Renal hypoxia and dysoxia after reperfusion of the ischemic kidney. Mol Med. 2008;14:502–516. doi: 10.2119/2008-00006.Legrand. - DOI - PMC - PubMed

[6] Legrand M, Mik EG, Johannes T, Payen D, Ince C. Renal hypoxia and dysoxia after reperfusion of the ischemic kidney. Mol Med. 2008;14:502–516. doi: 10.2119/2008-00006.Legrand. - DOI - PMC - PubMed

[7] Lei C, Berra L, Rezoagli E, Yu B, Dong H, Yu S, et al. Nitric oxide decreases acute kidney injury and stage 3 chronic kidney disease after cardiac surgery. Am J Respir Crit Care Med. 2018;198:1279–1287. doi: 10.1164/rccm.201710-2150OC. - DOI - PMC - PubMed

[8] Lei C, Berra L, Rezoagli E, Yu B, Dong H, Yu S, et al. Nitric oxide decreases acute kidney injury and stage 3 chronic kidney disease after cardiac surgery. Am J Respir Crit Care Med. 2018;198:1279–1287. doi: 10.1164/rccm.201710-2150OC. - DOI - PMC - PubMed

[9] Ruan S-Y, Huang T-M, Wu H-Y, Wu H-D, Yu C-J, Lai M-S. Inhaled nitric oxide therapy and risk of renal dysfunction: a systematic review and meta-analysis of randomized trials. Crit Care. 2015;19:137. doi: 10.1186/s13054-015-0880-2. - DOI - PMC - PubMed

[10] Ruan S-Y, Huang T-M, Wu H-Y, Wu H-D, Yu C-J, Lai M-S. Inhaled nitric oxide therapy and risk of renal dysfunction: a systematic review and meta-analysis of randomized trials. Crit Care. 2015;19:137. doi: 10.1186/s13054-015-0880-2. - DOI - PMC - PubMed

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Is nitric oxide the forgotten nephroprotective treatment during cardiac surgery?

Affiliations

Is nitric oxide the forgotten nephroprotective treatment during cardiac surgery?

Authors

Affiliations

Conflict of interest statement

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