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Review
. 2020 Apr;17(2):118-124.
doi: 10.1007/s11904-020-00486-2.

Novel Antiretroviral Agents

Mary C Cambou  1 , Raphael J Landovitz  2   3
Affiliations
Review

Novel Antiretroviral Agents

Mary C Cambou et al. Curr HIV/AIDS Rep. 2020 Apr.

Abstract

Purpose of review: Combination antiretroviral therapy (cART) has had dramatic effects on morbidity and mortality for persons living with HIV (PLWH). Despite significant progress in treatment efficacy, tolerability, and reducing pill burden, new agents are needed to address issues of resistance, drug-drug interactions, end organ disease, and adherence. This review covers novel ART agents recently approved or in development.

Recent findings: Capsid inhibitors (CAI) demonstrate high potency and potential for extended-duration dosing in pre-clinical trials. While previous maturation inhibitors (MI) were hampered by issues of drug resistance, a recent phase IIa trial for a second-generation MI demonstrated promising antiviral activity. A phase I trial to evaluate a transdermal implant of islatravir, a nucleoside reverse transcriptase translocation inhibitor (NRTTI), maintained concentrations above the target pharmacokinetic threshold at 12 weeks. The attachment inhibitor fostemsavir is available in the USA for compassionate use in multi-drug-resistant (MDR) HIV. New antiretroviral agents show promise for both extended-duration dosing and MDR HIV.

Keywords: Anti-CD4 antibodies; Capsid inhibitors; HIV/AIDS; Maturation inhibitors; New antiretrovirals; Nucleoside reverse transcriptase translocation inhibitors.

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Conflict of interest statement

Conflict of Interest: Dr. Landovitz received honoraria and travel support from Gilead Sciences, Merck, Inc, and Roche.

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