Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jul;98(7):1485-1497.
doi: 10.1002/jnr.24591. Epub 2020 Feb 12.

The emerging roles of circular RNAs in CNS injuries

Xiaolin Qu  1 , Zhenxing Li  1 , Jigang Chen  1 , Lijun Hou  1
Affiliations
Review

The emerging roles of circular RNAs in CNS injuries

Xiaolin Qu et al. J Neurosci Res. 2020 Jul.

Abstract

With high morbidity and mortality worldwide, injuries to the central nervous system (CNS) usually result in devastating consequences. However, the underlying mechanisms have not been fully understood and current therapies are still limited. Circular RNA (circRNA) is a novel type of endogenous noncoding RNAs, characterized by covalently closed annular structure. It is gradually recognized that circRNAs are involved in multiple biological processes, such as acting as microRNA sponges or scaffolds during the assembly of protein complex and modulating the transcription of certain genes. Interestingly, circRNAs have been found to be highly expressed in the CNS, which indicates their neurospecificity. Several circRNAs have already been discovered to be associated with multiple pathophysiological processes following neurological diseases. Currently, the molecular roles of circRNAs in CNS injuries have gained increasing attention, leading to uninterrupted relevant researches. Herein, we presented a review of current studies on the role of circRNAs in CNS injuries. The therapeutic potency of circRNAs in CNS injuries was also analyzed.

Keywords: circular RNA; spinal cord injury; stroke; traumatic brain injury.

PubMed Disclaimer

References

REFERENCES

    1. Aarum, J., Sandberg, K., Haeberlein, S. L., & Persson, M. A. (2003). Migration and differentiation of neural precursor cells can be directed by microglia. Proceedings of the National Academy of Sciences of the United States of America, 100(26), 15983-15988. https://doi.org/10.1073/pnas.2237050100
    1. Ahuja, C. S., Nori, S., Tetreault, L., Wilson, J., Kwon, B., Harrop, J., … Fehlings, M. G. (2017). Traumatic spinal cord injury-repair and regeneration. Neurosurgery, 80(Suppl. 3), S9-S22. https://doi.org/10.1093/neuros/nyw080
    1. Akhter, R. (2018). Circular RNA and Alzheimer's disease. Advances in Experimental Medicine and Biology, 1087, 239-243. https://doi.org/10.1007/978-981-13-1426-1_19
    1. Bai, Y., Zhang, Y., Han, B., Yang, L., Chen, X., Huang, R., … Hu, G. (2017). Circular RNA DLGAP4 ameliorates ischemic stroke outcomes by targeting miR-143 to regulate endothelial-mesenchymal transition associated with blood-brain barrier integrity. Journal of Neuroscience, 38(1), 32-50. https://doi.org/10.1523/jneurosci.1348-17.2017
    1. Bai, Y., Zhang, Y., Han, B., Yang, L., Chen, X., Huang, R., … Yao, H. (2018). Circular RNA DLGAP4 ameliorates ischemic stroke outcomes by targeting miR-143 to regulate endothelial-mesenchymal transition associated with blood-brain barrier integrity. Journal of Neuroscience, 38(1), 32-50. https://doi.org/10.1523/jneurosci.1348-17.2017

Publication types

LinkOut - more resources