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. 2020 May;50(5):585-596.
doi: 10.1111/cea.13586. Epub 2020 Feb 28.

Age-associated changes in chronic rhinosinusitis endotypes

Gwanghui Ryu  1 , Hun-Jong Dhong  2 , Minsu Park  3 , Na Young Hwang  3 , Dong-Kyu Kim  4 , Hyo Yeol Kim  5 , Seung-Kyu Chung  5 , Chae-Seo Rhee  6 , Seong-Ho Cho  7 , Sang Duk Hong  5 , Dae Woo Kim  8
Affiliations

Age-associated changes in chronic rhinosinusitis endotypes

Gwanghui Ryu et al. Clin Exp Allergy. 2020 May.

Abstract

Background: Immunologic function in innate and adaptive immunity changes with the ageing process. Thus, age-related cytokine profiles in chronic rhinosinusitis (CRS) need to be investigated for precision medicine.

Objective: The objective of this study was to characterize age-related changes in immunologic profiles according to CRS subtypes.

Methods: Subjects in control (n = 29), CRS without nasal polyps (CRSsNP, n = 86), and CRS with nasal polyps (eosinophilic NP: ENP, n = 81; non-eosinophilic NP: NENP, n = 113) were enrolled in this study. Twenty markers for type 1/2/3 inflammation and other inflammatory processes were measured in homogenates of sinonasal tissues and statistically analysed.

Results: In control tissues, type 2/3 and proinflammatory mediators showed an inverse correlation with age. CRSsNP and NENP showed an age-related increase in type 2 cytokines and a decline in type 3 cytokines. Interestingly, the age-related decrease in type 3 mediators was associated with those of CT scores in NENP. ENP showed an age-related increase in type 3 cytokines with type 2 mediators sustained at high levels. Smokers with ENP demonstrated age-associated increases in type 1/2/3 mediators as well as CT scores. These age-related patterns in each CRS were confirmed by statistically adjusting atopy status, smoking history, and disease duration.

Conclusion: Age-associated cytokine changes differed among CRS subtypes and control tissues. CRSsNP and NENP demonstrated a decline in type 3 mediators and increase in type 2 mediators, whereas type 3 mediators increased with age in ENP.

Keywords: age; cytokine; endotype; rhinosinusitis.

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References

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