Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1988 Nov;27(11):1097-101.
doi: 10.1016/0028-3908(88)90003-2.

Ethanol enhances the calcium-dependent stimulus-induced release of endogenous dopamine from slices of rat striatum and nucleus accumbens in vitro

B M Snape  1 , J A Engel
Affiliations
Comparative Study

Ethanol enhances the calcium-dependent stimulus-induced release of endogenous dopamine from slices of rat striatum and nucleus accumbens in vitro

B M Snape et al. Neuropharmacology. 1988 Nov.

Abstract

When slices of striatum from the rat were preincubated for 40 min in calcium-free medium in vitro, the subsequent release of endogenous dopamine (DA) induced by 40 mM KCl was completely calcium-dependent, showing a maximal response in the presence of 1.5 mM CaCl2, and a half-maximal response in the presence of 0.5 mM CaCl2. In this calcium-dependent preparation, ethanol, at concentrations of 80-120 mM, significantly increased the KCl-induced release of endogenous DA from the striatum by 19-29%. This effect was not reproducible in calcium-replete incubation medium (2.0 mM CaCl2), suggesting that the phenomenon was calcium-dependent. Preliminary studies in the nucleus accumbens of the rat showed a similar increase (30%) in the calcium-dependent, KCl-induced release of endogenous DA in the presence of 100 mM ethanol.

PubMed Disclaimer

Publication types