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. 2020 Aug;36(4):273-280.
doi: 10.3393/ac.2019.10.15. Epub 2019 Nov 13.

Long-term Oncologic Outcome of Postoperative Complications After Colorectal Cancer Surgery

Chang Kyu Oh  1 , Jung Wook Huh  1 , You Jin Lee  1 , Moon Suk Choi  1 , Dae Hee Pyo  1 , Sung Chul Lee  1 , Seong Mun Park  1 , Jung Kyong Shin  1 , Yoon Ah Park  1 , Yong Beom Cho  1 , Seong Hyeon Yun  1 , Hee Cheol Kim  1 , Woo Yong Lee  1
Affiliations

Long-term Oncologic Outcome of Postoperative Complications After Colorectal Cancer Surgery

Chang Kyu Oh et al. Ann Coloproctol. 2020 Aug.

Abstract

Purpose: The impact of postoperative complications on long-term oncologic outcome after radical colorectal cancer surgery is controversial. The aim of this study was to examine the risk factors and oncologic outcomes of surgery-related postoperative complication groups.

Methods: From January 2010 to December 2010, 310 patients experienced surgery-related postoperative complications after radical colorectal cancer surgery. These stage I-III patients were classified into 2 subgroups, minor (grades I, II) and major (grades III, IV) complication groups, according to extended Clavien-Dindo classification system criteria. Clinicopathologic differences between the 2 groups were analyzed to identify risk factors for major complications. The disease-free survival rates of surgery-related postoperative complication groups were also compared.

Results: Minor and major complication groups were stratified with 194 patients (62.6%) and 116 patients (37.4%), respectively. The risk factors influencing the major complication group were pathologic N category and operative method. The prognostic factors associated with disease-free survival were preoperative perforation, perineural invasion, tumor budding, and receiving neoadjuvant therapy. With a median follow-up period of 72.2 months, the 5-year disease-free survival rates were 84.4% in the minor group and 78.5% in the major group, but there was no statistical significance between the minor and major groups (P = 0.392).

Conclusion: Advanced cancer and open surgery were identified as risk factors for increased surgery-related major complications after radical colorectal cancer surgery. However, severity of postoperative complications did not affect disease-free survival from colorectal cancer.

Keywords: Colorectal cancer surgery; Postoperative complications; Recurrence; Risk factor.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1.
Fig. 1.
Disease-free survival (DFS) curves by postoperative complication group of Clavien-Dindo (CD) classification after colorectal cancer surgery.
Fig. 2.
Fig. 2.
Disease-free survival (DFS) curves according to pathologic TNM stage (pStage) after colorectal cancer surgery.
See this image and copyright information in PMC

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