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Published Erratum
. 2020 Feb 14;10(1):2992.
doi: 10.1038/s41598-020-60114-2.

Author Correction: Anti-apoptotic activity of ETB receptor agonist, IRL-1620, protects neural cells in rats with cerebral ischemia

Seema Briyal  1 , Amaresh K Ranjan  1 , Mary G Hornick  1 , Anupama K Puppala  1 , Thanh Luu  2 , Anil Gulati  3   4
Affiliations
Published Erratum

Author Correction: Anti-apoptotic activity of ETB receptor agonist, IRL-1620, protects neural cells in rats with cerebral ischemia

Seema Briyal et al. Sci Rep. .

Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Figures

Figure 1
Figure 1
Bax translocation to mitochondria in cerebral ischemia-induced apoptosis. Bax was immuno-stained with anti-Bax34, and the mitochondria were stained with MitoTracker (green). The merged image indicates colocalization of Bax on mitochondria. Values are expressed as mean ± S.E.M. *P < 0.01 compared to sham, @P < 0.001 compare to MCAO + vehicle.
Figure 2
Figure 2
TUNEL positive cells per 750 μm2 in the ischemic region were detected by TUNEL staining 24 h and day 7 after MCAO. Values are expressed as mean ± S.E.M. *p < 0.0001 compared to sham; @p < 0.001 compared to vehicle.
Figure 3
Figure 3
Effect of IRL-1620 on cerebral blood flow before, after and day 7 post MCAO in rat brains. Values are expressed as mean ± SEM. *P < 0.001 compared to sham; @P < 0.05 compared to MCAO + vehicle; $P < 0.0001 compared to IRL-1620 1 h post MCAO.
Figure 4
Figure 4
Effect of IRL-1620 on infarct volume in MCAO rats. 2 mm coronal sections of brains stained with TTC to visualize the infarct area 7 h, 24 h and day 7 post MCAO (red indicates normal tissue and white indicates infarct tissue). Values are expressed as mean ± SEM. *P < 0.001 compared to sham; @P < 0.05 compared to MCAO + vehicle.
Figure 5
Figure 5
Stimulation of ETB receptors by IRL-1620 can stimulate apoptotic signaling pathways which may be implicated in its neuroprotective effect.
See this image and copyright information in PMC

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