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Meta-Analysis
. 2020 Feb 13;10(1):2578.
doi: 10.1038/s41598-020-59564-5.

Comparison between Fissure Sealant and Fluoride Varnish on Caries Prevention for First Permanent Molars: a Systematic Review and Meta-analysis

Feifei Li  1   2 , Peipei Jiang  1   2 , Fanyuan Yu  1   2   3 , Chunjie Li  1   2 , Si Wu  1   2 , Jing Zou  1   2 , Xin Xu  1   2   3 , Ling Ye  1   2   3 , Xuedong Zhou  1   2   3 , Liwei Zheng  4   5
Affiliations
Meta-Analysis

Comparison between Fissure Sealant and Fluoride Varnish on Caries Prevention for First Permanent Molars: a Systematic Review and Meta-analysis

Feifei Li et al. Sci Rep. .

Abstract

The high prevalence and heavy socio-economic burden for caries of first permanent molars (FPMs) make the prevention of this disease a major public health goal. Current guidelines recommend a preference of fissure sealant (FS) over fluoride varnish (FV) based on two recent systematic reviews. However, evidences of these two studies are weak because of scarce data and some limitations. Besides, an up-to-date large scale randomized controlled trial (RCT) reported commensurate effectiveness of these two techniques. Thus, in order to more accurately compare the clinical efficacy between FS and FV on caries prevention for FPMs, we carried out this systematic review and meta-analysis. A total of 8 RCTs involving 3289 participants and 6878 FPMs fulfilled the inclusion criteria. Our meta-analysis for the first time showed that there was no statistical difference on caries incidence or occlusal DMFS increment between sealant group and fluoride varnish group at 2~3 years' follow-up. In that sense, biannual applications of FV or FS may be equally effective on caries prevention for FPMs. These results do not support routine recommendation of FS over FV, thus shedding light on current conceptions. Our findings endow clinicians with a window to reconsider the choice between these two techniques.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Search results and flow-chart of study selection for quantitative syntheses.
Figure 2
Figure 2
Bias assessment of included studies.
Figure 3
Figure 3
Meta-analysis for caries incidence (CI) after 2~3 years of follow-up. Forest plot of comparison: FS groups was compared with FV groups with respect to (A) CI of enrolled children (B) CI of FPMs (C) CI of FPMs’ occlusal surfaces.
Figure 4
Figure 4
Meta-analysis for occlusal DMFS increment of FPMs after 2~3 years of follow-up. Forest plot of comparison: FS groups was compared with FV groups with respect to occlusal DMFS increment of FPMs.
See this image and copyright information in PMC

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