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. 2018 Mar;26(1):10-15.
doi: 10.12793/tcp.2018.26.1.10. Epub 2018 Mar 16.

Development of R packages: ' NonCompart' and ' ncar' for noncompartmental analysis (NCA)

Hyungsub Kim  1 , Sungpil Han  1 , Yong-Soon Cho  1 , Seok-Kyu Yoon  1 , Kyun-Seop Bae  1
Affiliations

Development of R packages: ' NonCompart' and ' ncar' for noncompartmental analysis (NCA)

Hyungsub Kim et al. Transl Clin Pharmacol. 2018 Mar.

Erratum in

Abstract

Noncompartmental analysis (NCA) is a primary analytical approach for pharmacokinetic studies, and its parameters act as decision criteria in bioequivalent studies. Currently, NCA is usually carried out by commercial softwares such as WinNonlin®. In this article, we introduce our newly-developed two R packages, NonCompart (NonCompartmental analysis for pharmacokinetic data) and ncar (NonCompartmental Analysis for pharmacokinetic Report), which can perform NCA and produce complete NCA reports in both pdf and rtf formats. These packages are compatible with CDISC (Clinical Data Interchange Standards Consortium) standard as well. We demonstrate how the results of WinNonlin® are reproduced and how NCA reports can be obtained. With these R packages, we aimed to help researchers carry out NCA and utilize the output for early stages of drug development process. These R packages are freely available for download from the CRAN repository.

Keywords: NonCompart; R; ncar; noncompartmental analysis (NCA).

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Conflict of interest statement

Conflicts of interests: -Authors: The authors declare that they have no conflict of interests -Reviewers: Nothing to declare -Editors: Nothing to declare

Figures

Figure 1
Figure 1. Example of NonCompart package functions. Example by tblNCA.
Figure 2
Figure 2. Examples of ncar package functions. (A) Example of a NCA report in pdf format by pdfNCA, (B) Individual concentration-time plots (left: linear scale, right: log-linear scale).
See this image and copyright information in PMC

References

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