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Review
. 2021 Sep;109(3):339-350.
doi: 10.1007/s00223-020-00672-9. Epub 2020 Feb 13.

Prospects for Therapies in Osteoarthritis

Asim Ghouri  1 , Philip G Conaghan  2   3
Affiliations
Review

Prospects for Therapies in Osteoarthritis

Asim Ghouri et al. Calcif Tissue Int. 2021 Sep.

Abstract

Osteoarthritis (OA) is a chronic, debilitating disease affecting millions of people worldwide. Management of OA involves pharmacological and non-pharmacological approaches. Conventional pharmacological treatments have limited efficacy and are associated with a number of side-effects, restricting the number of patients who can use them. New pharmacological therapies for managing OA are required and a number have been developed targeting different tissues in OA: bone and cartilage, synovium and nerves. However, there has been overall limited success. Disease-modifying osteoarthritis drugs (DMOADs) are a putative class of therapies aimed at improving OA structural pathologies and consequent symptoms. Recent DMOAD studies have demonstrated some promising therapies but also provided new considerations for future trials.

Keywords: Cartilage; DMOAD; Inflammation; Nociceptive pain; Osteoarthritis; Synovitis.

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Conflict of interest statement

AG reports no conflicts. PGC reports speakers’ bureaus or consultancies for Abbvie, Astra Zeneca, BMS, Centrexion, EMD Serono, Flexion Therapeutics, Galapagos, GlaxoSmithKline, Novartis, Pfizer, Samumed and Stryker.

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