Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2020 Aug;48(4):489-495.
doi: 10.1007/s15010-019-01388-1. Epub 2020 Feb 13.

Non-influenza respiratory viruses in adult patients admitted with influenza-like illness: a 3-year prospective multicenter study

François Bénézit  1 , Paul Loubet  2 , Florence Galtier  3   4 , Charlotte Pronier  5 , Nezha Lenzi  2 , Zineb Lesieur  2 , Stéphane Jouneau  6   7 , Gisèle Lagathu  5 , Anne-Sophie L'Honneur  8 , Vincent Foulongne  9 , Christine Vallejo  10 , Sophie Alain  11 , Xavier Duval  12 , Nawal Houhou  13 , Yolande Costa  12 , Philippe Vanhems  14   15 , Sélilah Amour  14 , Fabrice Carrat  16 , Bruno Lina  17 , Odile Launay  2 , Pierre Tattevin  18   19 ; FLUVAC Study Group
Collaborators, Affiliations
Multicenter Study

Non-influenza respiratory viruses in adult patients admitted with influenza-like illness: a 3-year prospective multicenter study

François Bénézit et al. Infection. 2020 Aug.

Abstract

Purpose: To describe the burden, and characteristics, of influenza-like illness (ILI) associated with non-influenza respiratory viruses (NIRV).

Methods: We performed a prospective, multicenter, observational study of adults admitted with ILI during three influenza seasons (2012-2015). Patients were screened for picornavirus, respiratory syncytial virus (RSV), coronavirus, human metapneumovirus, adenovirus, bocavirus, parainfluenza virus, and influenza, by PCR on nasopharyngeal samples. We excluded patients coinfected with NIRV and influenza.

Results: Among 1421 patients enrolled, influenza virus was detected in 535 (38%), and NIRV in 215 (15%), mostly picornavirus (n = 61), RSV (n = 53), coronavirus 229E (n = 48), and human metapneumovirus (n = 40). In-hospital mortality was 5% (NIRV), 4% (influenza), and 5% (no respiratory virus). As compared to influenza, NIRV were associated with age (median, 73 years vs. 68, P = 0.026), chronic respiratory diseases (53% vs. 45%, P = 0.034), cancer (14% vs. 9%, P = 0.029), and immunosuppressive drugs (21% vs. 14%, P = 0.028), and inversely associated with diabetes (18% vs. 25%, P = 0.038). On multivariable analysis, only chronic respiratory diseases (OR 1.5 [1.1-2.0], P = 0.008), and diabetes (OR 0.5 [0.4-0.8], P = 0.01) were associated with NIRV detection.

Conclusions: NIRV are common in adults admitted with ILI during influenza seasons. Outcomes are similar in patients with NIRV, influenza, or no respiratory virus.

Keywords: Coronavirus; Human metapneumovirus; Influenza; Influenza-like illness; Picornavirus; Respiratory syncytial virus.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interest related to the study. O Launay is an investigator for clinical trials sponsored by Janssen and other companies and received travel support to attend scientific meetings from pharmaceutical companies.

Figures

Fig. 1
Fig. 1
Flowchart of patients hospitalized with influenza-like illness, and viruses detected in respiratory sample
See this image and copyright information in PMC

References

    1. Ruuskanen O, Lahti E, Jennings LC, Murdoch DR. Viral pneumonia. Lancet Lond Engl. 2011;377:1264–1275. doi: 10.1016/S0140-6736(10)61459-6. - DOI - PMC - PubMed
    1. Luchsinger V, Ruiz M, Zunino E, Martínez MA, Machado C, Piedra PA, et al. Community-acquired pneumonia in Chile: the clinical relevance in the detection of viruses and atypical bacteria. Thorax. 2013;68:1000–1006. doi: 10.1136/thoraxjnl-2013-203551. - DOI - PubMed
    1. van den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, Fouchier RAM, et al. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med. 2001;7:719–724. doi: 10.1038/89098. - DOI - PMC - PubMed
    1. Allander T, Tammi MT, Eriksson M, Bjerkner A, Tiveljung-Lindell A, Andersson B. Cloning of a human parvovirus by molecular screening of respiratory tract samples. Proc Natl Acad Sci USA. 2005;102:12891–12896. doi: 10.1073/pnas.0504666102. - DOI - PMC - PubMed
    1. Pavia AT. What is the role of respiratory viruses in community-acquired pneumonia? What is the best therapy for influenza and other viral causes of community-acquired pneumonia? Infect Dis Clin North Am. 2013;27:157–175. doi: 10.1016/j.idc.2012.11.007. - DOI - PMC - PubMed

Publication types