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Review
. 2020 May;92(5):491-494.
doi: 10.1002/jmv.25709. Epub 2020 Feb 21.

Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV

Jia Liu  1   2 , Xin Zheng  1   2 , Qiaoxia Tong  1 , Wei Li  1 , Baoju Wang  1   2 , Kathrin Sutter  3   2 , Mirko Trilling  3   2 , Mengji Lu  3   2 , Ulf Dittmer  3   2 , Dongliang Yang  1   2
Affiliations
Review

Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV

Jia Liu et al. J Med Virol. 2020 May.

Abstract

First reported from Wuhan, The People's Republic of China, on 31 December 2019, the ongoing outbreak of a novel coronavirus (2019-nCoV) causes great global concerns. Based on the advice of the International Health Regulations Emergency Committee and the fact that to date 24 other countries also reported cases, the WHO Director-General declared that the outbreak of 2019-nCoV constitutes a Public Health Emergency of International Concern on 30 January 2020. Together with the other two highly pathogenic coronaviruses, the severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), 2019-nCov and other yet to be identified coronaviruses pose a global threat to public health. In this mini-review, we provide a brief introduction to the pathology and pathogenesis of SARS-CoV and MERS-CoV and extrapolate this knowledge to the newly identified 2019-nCoV.

Keywords: coronavirus; immnopathology; immune responses; pathogenesis; respiratory tract; virus classification.

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Conflict of interest statement

The authors declare that there are no conflict of interests.

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