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. 2020 Jul;74(7):e22151.
doi: 10.1002/syn.22151. Epub 2020 Mar 3.

Investigating the effects of ebselen, a potential new lithium mimetic, on glutamate transmission

Filipa Mota  1 , Teresa Sementa  1 , Carlotta Taddei  1 , Natasha Moses  2 , Jayanta Bordoloi  1 , Stefan Hader  1 , Thomas Eykyn  1 , Diana Cash  2 , Federico Turkheimer  2 , Mattia Veronese  2 , Nisha Singh  1   2
Affiliations

Investigating the effects of ebselen, a potential new lithium mimetic, on glutamate transmission

Filipa Mota et al. Synapse. 2020 Jul.

Abstract

Ebselen, a potential new lithium-like drug, treatment reduced brain glutamate, as measured by PET imaging using the mGluR5 radioligand [18 F]FPEB in rats.

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References

REFERENCES

    1. Abdallah, C. G., Hannestad, J., Mason, G. F., Holmes, S. E., DellaGioia, N., Sanacora, G., … Esterlis, I. (2017). Metabotropic glutamate receptor 5 and glutamate involvement in major depressive disorder: A multimodal imaging study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2(5), 449-456. https://doi.org/10.1016/j.bpsc.2017.03.019
    1. Ametamey, S. M., Kessler, L. J., Honer, M., Wyss, M. T., Buck, A., Hintermann, S., … Schubiger, P. A. (2006). Radiosynthesis and preclinical evaluation of 11C-ABP688 as a probe for imaging the metabotropic glutamate receptor subtype 5. Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine, 47(4), 698-705.
    1. Coenen, H. H., Gee, A. D., Adam, M., Antoni, G., Cutler, C. S., Fujibayashi, Y., … Windhorst, A. D. (2017). Consensus nomenclature rules for radiopharmaceutical chemistry-Setting the record straight. Nuclear Medicine and Biology, 55, v-xi. https://doi.org/10.1016/j.nucmedbio.2017.09.004
    1. Dager, S. R., Friedman, S. D., Parow, A., Demopulos, C., Stoll, A. L., Lyoo, I. K., … Renshaw, P. F. (2004). Brain metabolic alterations in medication-free patients with bipolar disorder. Archives of General Psychiatry, 61(5), 450-458. https://doi.org/10.1001/archpsyc.61.5.450
    1. DeLorenzo, C., DellaGioia, N., Bloch, M., Sanacora, G., Nabulsi, N., Abdallah, C., … Esterlis, I. (2015). In vivo ketamine-induced changes in [11C]ABP688 binding to metabotropic glutamate receptor subtype 5. Biological Psychiatry, 77(3), 266-275. https://doi.org/10.1016/j.biopsych.2014.06.024

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