HIV-1 did not contribute to the 2019-nCoV genome

doi:10.1080/22221751.2020.1727299

. 2020 Feb 14;9(1):378-381.

doi: 10.1080/22221751.2020.1727299. eCollection 2020.

HIV-1 did not contribute to the 2019-nCoV genome

Chuan Xiao¹, Xiaojun Li², Shuying Liu³, Yongming Sang⁴, Shou-Jiang Gao⁵, Feng Gao^{2

6}

Affiliations

¹ Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, TX, USA.
² Department of Medicine, Duke University Medical Center, Durham, NC, USA.
³ NA BioTech Corp, M2D2 Incubator, University of Massachusetts Medical School, Worcester, MA, USA.
⁴ Department of Agricultural and Environmental Sciences, Tennessee State University, Nashville, TN, USA.
⁵ UPMC Hillman Cancer Center, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
⁶ National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, People's Republic of China.

PMID: 32056509
PMCID: PMC7033698
DOI: 10.1080/22221751.2020.1727299

HIV-1 did not contribute to the 2019-nCoV genome

Chuan Xiao et al. Emerg Microbes Infect. 2020.

. 2020 Feb 14;9(1):378-381.

doi: 10.1080/22221751.2020.1727299. eCollection 2020.

Authors

Chuan Xiao¹, Xiaojun Li², Shuying Liu³, Yongming Sang⁴, Shou-Jiang Gao⁵, Feng Gao^{2

6}

Affiliations

¹ Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, TX, USA.
² Department of Medicine, Duke University Medical Center, Durham, NC, USA.
³ NA BioTech Corp, M2D2 Incubator, University of Massachusetts Medical School, Worcester, MA, USA.
⁴ Department of Agricultural and Environmental Sciences, Tennessee State University, Nashville, TN, USA.
⁵ UPMC Hillman Cancer Center, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
⁶ National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, People's Republic of China.

PMID: 32056509
PMCID: PMC7033698
DOI: 10.1080/22221751.2020.1727299

No abstract available

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

**Figure 1.**
Sequence and structure analysis of 2019-nCoV and bat coronaviruses. (A) Phylogenetic tree analysis of the spike gene sequences. (B) Sequence alignment of suspected insertion sites between the 2019-nCoV and bat coronavirus sequences. The deletions in the alignment are shown as dashes. The numbers of insertions are indicated at the top of the alignment. (C) Structure comparison of the four insertions in the CoV spike protein and HIV-1 gp120. 2019-nCoV structure was modelled using I-TASSER server with default parameters. Only relevant domains with residues 1 to 708 (exclude residues from 305 to 603) were presented as ribbon diagram. The four insertions were labelled and coloured in red, blue, green and magenta, respectively. HIV-1 gp120 structure (PDB 1GC1) is presented as ribbon diagram. V4, V5, V1/V2 and LE loops were labelled and coloured in red, blue, green, and black, respectively.

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References

1. Gao F, Bailes E, Robertson DL, et al. . Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. Nature. 1999;397(6718):436–441. doi: 10.1038/17130 - DOI - PubMed
1. Li W, Shi Z, Yu M, et al. . Bats are natural reservoirs of SARS-like coronaviruses. Science (New York, NY). 2005 Oct 28:310(5748):676–679. doi: 10.1126/science.1118391 - DOI - PubMed
1. Azhar EI, El-Kafrawy SA, Farraj SA, et al. . Evidence for camel-to-human transmission of MERS coronavirus. N Engl J Med. 2014 Jun 26;370(26):2499–2505. doi: 10.1056/NEJMoa1401505 - DOI - PubMed
1. Wu F, Zhao S, Yu B, et al. . A new coronavirus associated with human respiratory disease in China. Nature. 2020. doi: 10.1038/s41586-020-2008-3 - DOI - PMC - PubMed
1. Zhu N, Zhang D, Wang W, et al. . A Novel coronavirus from patients with Pneumonia in China, 2019. N Engl J Med. 2020. doi: 10.1056/NEJMoa2001017 - DOI - PMC - PubMed

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[1] Gao F, Bailes E, Robertson DL, et al. . Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. Nature. 1999;397(6718):436–441. doi: 10.1038/17130 - DOI - PubMed

[2] Gao F, Bailes E, Robertson DL, et al. . Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. Nature. 1999;397(6718):436–441. doi: 10.1038/17130 - DOI - PubMed

[3] Li W, Shi Z, Yu M, et al. . Bats are natural reservoirs of SARS-like coronaviruses. Science (New York, NY). 2005 Oct 28:310(5748):676–679. doi: 10.1126/science.1118391 - DOI - PubMed

[4] Li W, Shi Z, Yu M, et al. . Bats are natural reservoirs of SARS-like coronaviruses. Science (New York, NY). 2005 Oct 28:310(5748):676–679. doi: 10.1126/science.1118391 - DOI - PubMed

[5] Azhar EI, El-Kafrawy SA, Farraj SA, et al. . Evidence for camel-to-human transmission of MERS coronavirus. N Engl J Med. 2014 Jun 26;370(26):2499–2505. doi: 10.1056/NEJMoa1401505 - DOI - PubMed

[6] Azhar EI, El-Kafrawy SA, Farraj SA, et al. . Evidence for camel-to-human transmission of MERS coronavirus. N Engl J Med. 2014 Jun 26;370(26):2499–2505. doi: 10.1056/NEJMoa1401505 - DOI - PubMed

[7] Wu F, Zhao S, Yu B, et al. . A new coronavirus associated with human respiratory disease in China. Nature. 2020. doi: 10.1038/s41586-020-2008-3 - DOI - PMC - PubMed

[8] Wu F, Zhao S, Yu B, et al. . A new coronavirus associated with human respiratory disease in China. Nature. 2020. doi: 10.1038/s41586-020-2008-3 - DOI - PMC - PubMed

[9] Zhu N, Zhang D, Wang W, et al. . A Novel coronavirus from patients with Pneumonia in China, 2019. N Engl J Med. 2020. doi: 10.1056/NEJMoa2001017 - DOI - PMC - PubMed

[10] Zhu N, Zhang D, Wang W, et al. . A Novel coronavirus from patients with Pneumonia in China, 2019. N Engl J Med. 2020. doi: 10.1056/NEJMoa2001017 - DOI - PMC - PubMed

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HIV-1 did not contribute to the 2019-nCoV genome

Affiliations

HIV-1 did not contribute to the 2019-nCoV genome

Authors

Affiliations

Conflict of interest statement

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