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. 2020 Apr;23(3):301-311.
doi: 10.1111/ner.13108. Epub 2020 Feb 14.

A Systematic Review of Noninvasive Brain Stimulation for Opioid Use Disorder

Heather B Ward  1   2 , Matthew J Mosquera  1   2 , Joji Suzuki  1   2 , Timothy Y Mariano  1   2   3   4
Affiliations

A Systematic Review of Noninvasive Brain Stimulation for Opioid Use Disorder

Heather B Ward et al. Neuromodulation. 2020 Apr.

Abstract

Background: There is a great public health need to identify novel treatment strategies for opioid use disorder (OUD) in order to reduce relapse and overdose. Noninvasive brain stimulation (NIBS) has demonstrated preliminary effectiveness for substance use, but little is known about its use in OUD. Neuromodulation may represent a potential adjunctive treatment modality for OUD, so we conducted a systematic review to understand the state of the current research in this field.

Methods: We conducted a systematic review of studies using noninvasive brain stimulation to affect clinical outcomes related to substance use for adults with opioid use disorder. We searched the following online databases: PubMed, The Cochrane Library, PsycINFO (EBSCOhost, 1872-present), and Science Citation Index Expanded (ISI Web of Science, 1945-present). All studies that measured clinical outcomes related to substance use, including cue-induced craving, were included. We assessed risk of bias using the Cochrane Handbook.

Results: The initial search yielded 5590 studies after duplicates were removed. After screening titles and abstracts, 14 full-text studies were assessed for eligibility. Five studies were determined to meet inclusion criteria with a combined total subjects of N = 150. Given the paucity of studies and small number of total subjects, no quantitative analysis was performed. These studies used TMS (n = 3), tDCS (n = 1), and the BRIDGE device (n = 1), a noninvasive percutaneous electrical nerve field stimulator, to reduce cue-induced craving (n = 3), reduce clinical withdrawal symptoms (n = 1), or measure substance-use-related cortical plasticity (n = 1).

Conclusions: There is a dearth of research in the area of noninvasive brain stimulation for OUD. NIBS represents a novel treatment modality that should be further investigated for OUD.

Keywords: Addiction; noninvasive brain stimulation; opioid use disorder; transcranial direct current stimulation; transcranial magnetic stimulation.

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Conflict of interest statement

Conflict of Interest: Timothy Y. Mariano is an employee of Sage Therapeutics, Inc., has served on an advisory board for Janssen Pharmaceuticals and has been a consultant for Ad Scientiam-all outside the scope of the present work. The other authors have no conflicts of interest to disclose. The contents do not represent the views of the Department of Veterans Affairs or the United States Government.

For more information on author guidelines, an explanation of our peer review process, and conflict of interest informed consent policies, please go to http://www.wiley.com/WileyCDA/Section/id-301854.html

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References

    1. Center for Behavioral Health Statistics and Quality. Key substance use and mental health indicators in the United States: Results from the 2015 national survey on drug use and health. Substance Abuse and Mental Health Services Administration, editor. Rockville, MD: U.S. Department of Health and Human Services, 2016.
    1. Jones CM, Einstein EB, Compton WM. Changes in synthetic opioid involvement in drug overdose deaths in the United States, 2010-2016. JAMA 2018;319:1819–1821. - PMC - PubMed
    1. Clark RE, Baxter JD, Aweh G, O’Connell E, Fisher WH, Barton BA. Risk factors for relapse and higher costs among medicaid members with opioid dependence or abuse: Opioid agonists, comorbidities, and treatment history. J Subst Abuse Treat 2015;57:75–80. - PMC - PubMed
    1. Ferri M, Finlayson AJ, Wang L, Martin PR. Predictive factors for relapse in patients on buprenorphine maintenance. Am J Addict 2014;23:62–67. - PMC - PubMed
    1. Substance Abuse and Mental Health Services Administration. Medications for opioid use disorder. U.S. Department of Health and Human Services, editor. Rockville, MD: U.S. Department of Health and Human Services, 2018.

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