Placenta and perinatal brain injury: the gateway to individualized therapeutics and precision neonatal medicine
- PMID: 32059230
- PMCID: PMC10097459
- DOI: 10.1038/s41390-020-0807-8
Placenta and perinatal brain injury: the gateway to individualized therapeutics and precision neonatal medicine
Abstract
Wu and colleagues analyzed the placental pathology from a subset of the neonates in the NEATO trial who had reports available and correlated the placental pathology findings with outcomes. This study highlights the importance of placental pathology, and its potential to bring precision medicine to critically-ill neonates. Placental pathology will likely aid stratification of neonates for clinical trials and accelerate progress for neurorepair.
Conflict of interest statement
Comment on
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Placental pathology and neonatal brain MRI in a randomized trial of erythropoietin for hypoxic-ischemic encephalopathy.Pediatr Res. 2020 Apr;87(5):879-884. doi: 10.1038/s41390-019-0493-6. Epub 2019 Jul 1. Pediatr Res. 2020. PMID: 31261373 Clinical Trial.
References
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- Wu YW et al. High-dose erythropoietin and hypothermia for hypoxic–ischemic encephalopathy: a phase II trial. Pediatrics 137, e20160191 (2016). - PubMed
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- Shallie PD & Naicker T The placenta as a window to the brain: a review on the role of placental markers in prenatal programming of neurodevelopment. Int. J. Dev. Neurosci 73, 41–49 (2019). - PubMed
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- Vik T et al. The placenta in neonatal encephalopathy: a case–control study. J. Pediatr 202, 77–85.e3 (2018). - PubMed
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