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. 2020 Feb 12;12(2):423.
doi: 10.3390/cancers12020423.

Does the TT Variant of the rs966423 Polymorphism in DIRC3 Affect the Stage and Clinical Course of Papillary Thyroid Cancer?

Kinga Hińcza  1 , Artur Kowalik  1 , Iwona Pałyga  2   3 , Agnieszka Walczyk  3 , Danuta Gąsior-Perczak  3 , Estera Mikina  3 , Tomasz Trybek  3 , Monika Szymonek  3 , Klaudia Gadawska-Juszczyk  3 , Klaudia Zajkowska  3 , Agnieszka Suligowska  3 , Artur Kuchareczko  3 , Karol Krawczyk  1 , Janusz Kopczyński  4 , Magdalena Chrapek  5 , Stanisław Góźdź  2   6 , Aldona Kowalska  2   3
Affiliations

Does the TT Variant of the rs966423 Polymorphism in DIRC3 Affect the Stage and Clinical Course of Papillary Thyroid Cancer?

Kinga Hińcza et al. Cancers (Basel). .

Abstract

Thyroid cancer (TC) is the most common cancer of the endocrine system. Most new diagnoses are of low-grade papillary thyroid cancer (PTC), suggesting that PTC may be over-diagnosed. However, the incidence of advanced-stage PTC has increased in recent years. It is therefore very important to identify prognostic factors for advanced PTC. Somatic mutation of the BRAF gene at V600E, or the coexistence of the BRAF V600E mutation and mutations in the TERT promoter are associated with more aggressive disease. It would also be valuable to identify genetic risk factors affecting PTC prognosis. We therefore evaluated the impact of the rs966423 polymorphism in the DIRC3 gene, including its relationship with unfavorable histopathological and clinical features and mortality, in differentiated thyroid cancer (DTC). The study included 1466 patients diagnosed with DTC from one center. There was no significant association between the DIRC3 genotype at rs966423 (CC, CT, or TT) and any histopathological or clinic factor examined, including initial response to therapy, response at follow-up, or overall mortality, in DTC patients.

Keywords: overdiagnosis; overtreatment; papillary thyroid cancer; risk factors.

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Conflict of interest statement

The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

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