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. 2020 Feb 14;13(1):19.
doi: 10.1186/s13048-020-00619-6.

Characteristics and treatment results of recurrence in adult-type granulosa cell tumor of ovary

Dan Zhao  1 , Yanan Zhang  1 , Zhengjie Ou  1 , Rong Zhang  1 , Shan Zheng  2 , Bin Li  3
Affiliations

Characteristics and treatment results of recurrence in adult-type granulosa cell tumor of ovary

Dan Zhao et al. J Ovarian Res. .

Abstract

Background: The aim of this study was to explore the clinicopathological characteristics of recurrent adult-type granulosa cell tumor of the ovary (AGCOT) and evaluated the treatment results to define the prognostic parameters for survival after recurrence.

Results: A retrospective review of 40 patients with recurrent AGCOT, who were treated in the Cancer Hospital at the Chinese Academy of Medical Sciences from 2000 to 2015 was conducted. The impact of clinical and pathological characteristics, progression-free survival (PFS), and post-recurrence therapeutic approaches on prognosis were analyzed. Among the 40 recurrent patients, there were 10 cases where the relapse was uncontrolled, 24 cases had second relapses, and 6 cases without further relapses at the time of our follow-up. The median PFS was 61 months (range, 7-408 months), and the median time interval between the first and the second relapses (R-PFS) was 25 months (range, 0-94 months). The median time interval between the first relapse and death (R-OS) was 90 months (range, 2-216 months). PFS ≥ 61 months (P = 0.004) and post-recurrence therapeutic approach (P < 0.001) were independent risk factors for repeated recurrences. The age at recurrence (P = 0.031) and post-recurrence therapeutic approach (P = 0.001) were independent risk factors for death after recurrence.

Conclusion: Among patients with recurrent AGCOT, those with long PFS had good prognoses. Maximal cytoreductive effort should be made after recurrence. Complete resection and postoperative adjuvant chemotherapy may improve the prognosis of patients with recurrent AGCOT.

Keywords: Adult granulosa cell tumor; Ovarian granulosa cell tumor; Prognosis; Recurrent granulosa cell tumor.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Clinical outcomes of 40 patients with recurrent AGCOT, including 18 deaths and 22 survival cases. Abbreviations: s, surgery; c, chemotherapy
Fig. 2
Fig. 2
R-PFS according to PFS (a) and post-recurrence therapeutic approaches (b). R-OS according to post-recurrence therapeutic approaches (c) and post-recurrence complete resection (d). Abbreviations: R-PFS, Time interval between the first and the second relapses; c, chemotherapy; R-OS, Time interval between the first relapse and death; PFS, progression-free survival.
See this image and copyright information in PMC

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