PARP1/2 and Accessory Factor HPF1 Interlock to Form a Joint Active Site
- PMID: 32060056
- DOI: 10.1158/2159-8290.CD-RW2020-024
PARP1/2 and Accessory Factor HPF1 Interlock to Form a Joint Active Site
Abstract
Structural analyses showed that HPF1 contributed amino acid residues to the PARP1/2 active site.
©2020 American Association for Cancer Research.
Comment on
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HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.Nature. 2020 Mar;579(7800):598-602. doi: 10.1038/s41586-020-2013-6. Epub 2020 Feb 6. Nature. 2020. PMID: 32028527 Free PMC article.
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