Small-molecule inhibitors get pro-inflammatory TNF into shape

Savvas N Savvides^{1

2}, Dirk Elewaut^{3

4}

Affiliations

¹ VIB-UGent Center for Inflammation Research, Ghent, Belgium. savvas.savvides@ugent.be.
² Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium. savvas.savvides@ugent.be.
³ VIB-UGent Center for Inflammation Research, Ghent, Belgium.
⁴ Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, Ghent University Hospital, Ghent, Belgium.

Comment

Savvas N Savvides et al. Nat Rev Rheumatol. 2020 Apr.

. 2020 Apr;16(4):189-190.

doi: 10.1038/s41584-020-0388-2.

Savvas N Savvides^{1

2}, Dirk Elewaut^{3

4}

¹ VIB-UGent Center for Inflammation Research, Ghent, Belgium. savvas.savvides@ugent.be.
² Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium. savvas.savvides@ugent.be.
³ VIB-UGent Center for Inflammation Research, Ghent, Belgium.
⁴ Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, Ghent University Hospital, Ghent, Belgium.

No abstract available

Comment on

Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer.
O'Connell J, Porter J, Kroeplien B, Norman T, Rapecki S, Davis R, McMillan D, Arakaki T, Burgin A, Fox Iii D, Ceska T, Lecomte F, Maloney A, Vugler A, Carrington B, Cossins BP, Bourne T, Lawson A. O'Connell J, et al. Nat Commun. 2019 Dec 19;10(1):5795. doi: 10.1038/s41467-019-13616-1. Nat Commun. 2019. PMID: 31857588 Free PMC article.

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