A small molecule kicks repeat expansion into reverse
- PMID: 32060488
- DOI: 10.1038/s41588-020-0577-6
A small molecule kicks repeat expansion into reverse
Comment on
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A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo.Nat Genet. 2020 Feb;52(2):146-159. doi: 10.1038/s41588-019-0575-8. Epub 2020 Feb 14. Nat Genet. 2020. PMID: 32060489 Free PMC article.
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References
-
- Neil, A. J., Kim, J. C. & Mirkin, S. M. BioEssays 39, 1700077 (2017). - DOI
-
- Kennedy, L. et al. Hum. Mol. Genet. 12, 3359–3367 (2003). - DOI
-
- Thornton, C. A., Johnson, K. & Moxley, R. T. III Ann. Neurol. 35, 104–107 (1994). - DOI
-
- Ciosi, M. et al. EBioMedicine 48, 568–580 (2019). - DOI
-
- Pinto, R. M. et al. PLoS Genet. 9, e1003930 (2013). - DOI
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