Higher risk of stent thrombosis with double therapy with direct oral anticoagulants: cherry picking the populations of interest does not help

Giuseppe Gargiulo¹, Andreas Goette^{2

3

4}, Pascal Vranckx⁵, Marco Valgimigli⁶

Affiliations

¹ Department of Advanced Biomedical Sciences, Federico II University of Naples, Via S. Pansini 5, 80131 Naples, Italy.
² St. Vincenz-Hospital, Am Busdorf 2, 33098 Paderborn, Germany.
³ Working Group of Molecular Electrophysiology, University Hospital Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.
⁴ Atrial Fibrillation Network (AFNET), Mendel Str. 11, 48149 Münster, Germany.
⁵ Department of Cardiology and Intensive Care Medicine, Jessa Ziekenhuis, Faculty of Medicine and Life Sciences at the Hasselt University, Stadsomvaart 11, 3500 Hasselt, Belgium.
⁶ Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 10, 3010 Bern, Switzerland.

Comment

Giuseppe Gargiulo et al. Eur Heart J. 2020.

. 2020 May 1;41(17):1701-1702.

doi: 10.1093/eurheartj/ehaa076.

Giuseppe Gargiulo¹, Andreas Goette^{2

3

4}, Pascal Vranckx⁵, Marco Valgimigli⁶

¹ Department of Advanced Biomedical Sciences, Federico II University of Naples, Via S. Pansini 5, 80131 Naples, Italy.
² St. Vincenz-Hospital, Am Busdorf 2, 33098 Paderborn, Germany.
³ Working Group of Molecular Electrophysiology, University Hospital Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.
⁴ Atrial Fibrillation Network (AFNET), Mendel Str. 11, 48149 Münster, Germany.
⁵ Department of Cardiology and Intensive Care Medicine, Jessa Ziekenhuis, Faculty of Medicine and Life Sciences at the Hasselt University, Stadsomvaart 11, 3500 Hasselt, Belgium.
⁶ Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 10, 3010 Bern, Switzerland.

No abstract available

Comment on

1. Gargiulo G, Goette A, Tijssen J, Eckardt L, Lewalter T, Vranckx P, Valgimigli M.. Safety and efficacy outcomes of double vs. triple antithrombotic therapy in patients with atrial fibrillation following percutaneous coronary intervention: a systematic review and meta-analysis of non-vitamin K antagonist oral anticoagulant-based randomized clinical trials. Eur Heart J 2019;40:3757–3767. - PubMed
1. Lopes RD, Leonardi S, Wojdyla DM, Vora AN, Thomas L, Storey RF, Vinereanu D, Granger CB, Goodman SG, Aronson R, Windecker S, Thiele H, Valgimigli M, Mehran R, Alexander JH.. Stent thrombosis in patients with atrial fibrillation undergoing coronary stenting in the AUGUSTUS trial. Circulation 2019;doi:10.1161/CIRCULATIONAHA.119.044584. - PubMed
1. Vranckx P, Valgimigli M, Eckardt L, Tijssen J, Lewalter T, Gargiulo G, Batushkin V, Campo G, Lysak Z, Vakaliuk I, Milewski K, Laeis P, Reimitz PE, Smolnik R, Zierhut W, Goette A.. Edoxaban-based versus vitamin K antagonist-based antithrombotic regimen after successful coronary stenting in patients with atrial fibrillation (ENTRUST-AF PCI): a randomised, open-label, phase 3b trial. Lancet 2019;394:1335–1343. - PubMed