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Review
. 2020 Aug;39(8):1405-1425.
doi: 10.1007/s10096-020-03843-6. Epub 2020 Feb 15.

Tuberculosis vaccine development: from classic to clinical candidates

Junli Li  1   2   3   4 , Aihua Zhao  5 , Jun Tang  1   2   3   4 , Guozhi Wang  5 , Yanan Shi  1   2   3   4 , Lingjun Zhan  6   7   8   9 , Chuan Qin  10   11   12   13
Affiliations
Review

Tuberculosis vaccine development: from classic to clinical candidates

Junli Li et al. Eur J Clin Microbiol Infect Dis. 2020 Aug.

Abstract

Bacillus Calmette-Guérin (BCG) has been in use for nearly 100 years and is the only licensed TB vaccine. While BCG provides protection against disseminated TB in infants, its protection against adult pulmonary tuberculosis (PTB) is variable. To achieve the ambitious goal of eradicating TB worldwide by 2050, there is an urgent need to develop novel TB vaccines. Currently, there are more than a dozen novel TB vaccines including prophylactic and therapeutic at different stages of clinical research. This literature review provides an overview of the clinical status of candidate TB vaccines and discusses the challenges and future development trends of novel TB vaccine research in combination with the efficacy of evaluation of TB vaccines, provides insight for the development of safer and more efficient vaccines, and may inspire new ideas for the prevention of TB.

Keywords: BCG; Clinical trial; MTB; Novel TB vaccine; TB.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
History and genealogy of BCG substrains. RD1 was missing from all BCG substrains and coincides with the attenuated virulence of M. bovis. From the top to the bottom of the timeline, BCG substrains are divided into “Early” strains and “Late” strains. In “Early” strains, the original characteristics of “authentic Pasteur” were conserved with fewer deletions, insertions, and mutations in the genome of the bacilli than the “Late” strains
See this image and copyright information in PMC

References

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MeSH terms

Substances