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Review
. 2020:1231:53-65.
doi: 10.1007/978-3-030-36667-4_6.

CCL20 Signaling in the Tumor Microenvironment

Weilong Chen  1   2   3 , Yuanyuan Qin  1   2   3 , Suling Liu  4   5   6
Affiliations
Review

CCL20 Signaling in the Tumor Microenvironment

Weilong Chen et al. Adv Exp Med Biol. 2020.

Abstract

CCL20, as a chemokine, plays an important role in rheumatoid arthritis, psoriasis, and other diseases by binding to its receptor CCR6. Recent 10 years' research has demonstrated that CCL20 also contributes to the progression of many cancers, such as liver cancer, colon cancer, breast cancer, pancreatic cancer, and gastric cancer. This article reviews and discusses the previous studies on CCL20 roles in cancers from the aspects of its specific effects on various cancers, its remodeling on tumor microenvironment (TME), its synergistic effects with other cytokines in tumor microenvironment, and the specific mechanisms of CCL20 signal activation, illustrating CCL20 signaling in TME from multiple directions.

Keywords: CCL20; CCR6; Cancer; Chemokine; Cytokine; Dendritic cells (DCs); NF-κB; Regulatory T cells (Tregs); T helper 17 cells (Th17 cells); Tumor microenvironment (TME).

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