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Comment
. 2020 Mar;41(3):187-189.
doi: 10.1016/j.it.2020.01.008. Epub 2020 Feb 12.

CD38: Modulating Histone Methyltransferase EZH2 Activity in SLE

Paramita Chakraborty  1 , Shikhar Mehrotra  2
Affiliations
Comment

CD38: Modulating Histone Methyltransferase EZH2 Activity in SLE

Paramita Chakraborty et al. Trends Immunol. 2020 Mar.

Abstract

To keep autoreactive T cells under control in SLE patients, immunosuppressive regimens are used, which can increase susceptibility to bacterial and viral infections. Recently, Katsuyama et al., demonstrated that the CD38/NAD/Sirtuin1/EZH2 axis reduces cytolytic CD8+ T cell function and might be targeted to overcome incidence of infections.

Keywords: CD38; EZH2; SLE; T cells; methylation.

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