Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jan 28;4(1):rkaa001.
doi: 10.1093/rap/rkaa001. eCollection 2020.

Nivolumab-induced eosinophilic fasciitis: a case report

Natasha Ollier  1 , Emilie Tournier  2 , Nicolas Meyer  3 , Vincent Sibaud  3 , Cécile Pages-Laurent  3 , Pierre Cougoul  1 , Odile Beyne-Rauzy  1 , Thibault Comont  1
Affiliations

Nivolumab-induced eosinophilic fasciitis: a case report

Natasha Ollier et al. Rheumatol Adv Pract. .
No abstract available

PubMed Disclaimer

Figures

<sc>Fig</sc>. 1
Fig. 1
Clinical, morphological and histological features of eosinophilic fasciitis at diagnosis and outcome after treatment (A) Groove sign, a linear depression in the skin parallel to the course of the superficial veins. (B) Inflammatory infiltrates (lymphocytes, plasmocytes and eosinophils) in the fascia and muscle (leg biopsy, standard coloration, ×10 magnification). (C) MRI findings at diagnosis (March 2019; C1) and after treatment with MTX and IVIG (December 2019; C2) (D) PET–tomodensitometry findings at diagnosis (March 2019; D1) and after treatment (December 2019; D2).
See this image and copyright information in PMC

References

    1. Kostine M, Rouxel L, Barnetche T. et al. Rheumatic disorders associated with immune checkpoint inhibitors in patients with cancer—clinical aspects and relationship with tumour response: a single-centre prospective cohort study. Ann Rheum Dis 2018;77:393–8. - PubMed
    1. Khoja L, Maurice C, Chappell M. et al. Eosinophilic fasciitis and acute encephalopathy toxicity from pembrolizumab treatment of a patient with metastatic melanoma. Cancer Immunol Res 2016;4:175–8. - PubMed
    1. Toussaint F, Hammon M, Erdmann M. et al. Checkpoint inhibitor-induced eosinophilic fasciitis following high eosinophilia associated with complete response. Rheumatology 2019;58:1875–7. - PubMed
    1. Parker MJ, Roberts ME, Lorigan PC, du Plessis DG, Chinoy H.. Autoimmune fasciitis triggered by the anti-programmed cell death-1 monoclonal antibody nivolumab. BMJ Case Rep 2018;2018:bcr2017223249. - PMC - PubMed
    1. Lebeaux D, Francès C, Barete S. et al. Eosinophilic fasciitis (Shulman disease): new insights into the therapeutic management from a series of 34 patients. Rheumatology 2012;51:557–61. - PubMed

LinkOut - more resources