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Meta-Analysis
. 2020 Jun;52(6):999-1008.
doi: 10.1007/s11255-020-02408-y. Epub 2020 Feb 17.

Meta-analysis and systematic review of intermediate-term follow-up of prostatic urethral lift for benign prostatic hyperplasia

Karthik Tanneru  1 , Shiva Gautam  2 , Daniel Norez  2 , Jatinder Kumar  1 , Muhammad Umar Alam  1 , Shahriar Koocheckpour  1 , K C Balaji  1 , Costa Joseph  3
Affiliations
Meta-Analysis

Meta-analysis and systematic review of intermediate-term follow-up of prostatic urethral lift for benign prostatic hyperplasia

Karthik Tanneru et al. Int Urol Nephrol. 2020 Jun.

Abstract

Background: Prostatic urethral lift (PUL), is a relatively new minimally invasive procedure for treatment of benign prostatic hyperplasia (BPH).This article is a systematic review and meta-analysis of all the articles published including follow-up of at least 24 months to analyze sustainability of results.

Methods: We performed a critical review in according to the preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines. From a total 768 published articles that matched our search terms, 5 studies with minimum follow-up of 24 months were selected for comparison and data analyzed in terms of baseline characteristics, functional, and sexual health outcomes.

Results: Included in the analyses are five studies with a minimum follow-up of 24 months. A total of 386 patients underwent PUL and 322 patients (83.4%) are available for follow-up at 24 months. The randomized studies are grouped as group A and non-randomized studies as group B. At 24 months, the mean reduction in International Prostate Symptom Score (IPSS) from baseline was 9.1 in group A and 10.4 in group B. The mean improvement in peak flow rate (Qmax) was 3.7 mL/s in group A and 3 mL/s in group B, and quality of life (QoL) improved by 2.2 in both groups.

Conclusion: PUL is a well-tolerated, minimally invasive therapy for BPH that provides favorable and durable symptomatic, sexual health, and functional outcomes up to 24 months. Longer follow-up and randomized studies comparing to current standards are required to further confirm the long-term sustainability of PUL.

Keywords: BPH; LUTS; PUL; Prostatic urethral lift; Urolift.

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References

    1. St Sauver JL, Jacobson DJ, Girman CJ, Lieber MM, McGree ME, Jacobsen SJ (2006) Tracking of longitudinal changes in measures of benign prostatic hyperplasia in a population based cohort. J Urol 175(3 Pt 1):1018–1022. https://doi.org/10.1016/s0022-5347(05)00408-8 (discussion 980) - DOI - PubMed
    1. Ally M, Lee T, Ecclestone H, Teo L, Kavia R (2017) Malignant features of a benign waiting list. J Clin Urol 10(2):105–109 - DOI
    1. Roehrborn CG (2011) Male lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH). Med Clin 95(1):87–100
    1. Verhamme KM, Dieleman JP, Bleumink GS, Bosch JL, Stricker BH, Sturkenboom MC (2003) Treatment strategies, patterns of drug use and treatment discontinuation in men with LUTS suggestive of benign prostatic hyperplasia: the Triumph project. Eur Urol 44(5):539–545. https://doi.org/10.1016/s0302-2838(03)00376-2 - DOI - PubMed
    1. Rassweiler J, Teber D, Kuntz R, Hofmann R (2006) Complications of transurethral resection of the prostate (TURP)–incidence, management, and prevention. Eur Urol 50(5):969–979. https://doi.org/10.1016/j.eururo.2005.12.042 (discussion 980) - DOI - PubMed

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