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. 2020 Feb 17;10(2):18.
doi: 10.1038/s41408-020-0285-6.

Identification of the true hyperdiploid multiple myeloma subset by combining conventional karyotyping and FISH analysis

Gregorio Barilà  1 , Laura Bonaldi  2 , Angela Grassi  2 , Annalisa Martines  2 , Albana Liço  1 , Nadia Macrì  2 , Silvia Nalio  2 , Laura Pavan  1 , Tamara Berno  1 , Antonio Branca  1 , Giulia Calabretto  1 , Marilena Carrino  1 , Antonella Teramo  1 , Sabrina Manni  1 , Francesco Piazza  1 , Gianpietro Semenzato  1 , Renato Zambello  3
Affiliations

Identification of the true hyperdiploid multiple myeloma subset by combining conventional karyotyping and FISH analysis

Gregorio Barilà et al. Blood Cancer J. .
No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1. Kaplan–Meier curves showing overall survival of HRD MM patients according to cytogenetic and FISH features.
a According to the number of FISH alterations (≥2 or <2) (p = 0.0123). b Based on the presence or absence of IGH rearrangement (p = 0.0319). c According to the presence of 1q gain (p = 0.0929). d Depending on the transplant status (p = 0.0465). e According to the concomitant presence of 9/11/15 trisomies (p = 0.0218). f Based on T-HRD MM (≥5 trisomies) and N-HRD MM (<5 trisomies) classification (p = 0.0105). The comparisons between groups were made by log-rank test. HRD MM hyperdiploid multiple myeloma, FISH fluorescent in situ hybridization, IGH immunoglobulin heavy locus, ASCT autologous stem cell transplantation, N-HRD MM non-trisomic hyperdiploid multiple myeloma, T-HRD MM trisomic hyperdiploid multiple myeloma.
See this image and copyright information in PMC

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