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Multicenter Study
. 2020 May;40(5):781-789.
doi: 10.1038/s41372-020-0614-4. Epub 2020 Feb 17.

Medications and in-hospital outcomes in infants born at 22-24 weeks of gestation

Mihai Puia-Dumitrescu  1   2 , Noelle Younge  2 , Daniel K Benjamin  3 , Katie Lawson  4 , Cordelia Hume  4 , Kennedy Hill  4 , Jonathan Mengistu  4 , Aryeona Wilson  4 , Kanecia O Zimmerman  2   4 , Kaashif Ahmad  5 , Rachel G Greenberg  6   7
Affiliations
Multicenter Study

Medications and in-hospital outcomes in infants born at 22-24 weeks of gestation

Mihai Puia-Dumitrescu et al. J Perinatol. 2020 May.

Abstract

Objective: To evaluate the most commonly used medications and in-hospital morbidities and mortality in infants born 22-24 weeks of gestation.

Study design: Multicenter retrospective cohort study of infants born 22-24 weeks of gestation (2006-2016), without major congenital anomalies and with available medication data obtained from neonatal intensive care units managed by the Pediatrix Medical Group.

Results: This study included 7578 infants from 195 sites. Median (25th, 75th percentile): birthweight was 610 g (540, 680); the number of distinct medications used was 13 (8, 18); and different antimicrobial exposure was 4 (2, 5). The most common morbidities were BPD (41%) and grade III or IV IVH (20%), and overall survival varied from 46% (2006) to 57% (2016).

Conclusions: A large number of medications were used in periviable infants. There was a high prevalence of in-hospital morbidities, and survival of this population increased over the study period.

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Conflict of interest statement

Conflict of interest NY received support from the NIH (K23DK12 0960). MP-D, DKB, KL, CH, KH, JM, AW, KOZ, KA, and RGG report no relevant disclosures.

Figures

Fig. 1
Fig. 1. Number of medications and survival by site.
a medication use across sites: distribution of the median number of medications to which a periviable infant was exposed during the study period; and b survival among sites with >20 infants: distribution of the proportion of infants 22–24 weeks GA who survived to discharge. GA gestational age.
Fig. 2
Fig. 2. Survival by GA.
Survival rates among infants born at 22–24 weeks GA, from 2006 to 2016. GA gestational age.
See this image and copyright information in PMC

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