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Case Reports
. 2020 Jun;52(6):419-422.
doi: 10.1080/23744235.2020.1729403. Epub 2020 Feb 18.

Fatal encephalitis associated with coronavirus OC43 in an immunocompromised child

Anna Nilsson  1 , Niklas Edner  2 , Jan Albert  3   4 , Anders Ternhag  5
Affiliations
Free article
Case Reports

Fatal encephalitis associated with coronavirus OC43 in an immunocompromised child

Anna Nilsson et al. Infect Dis (Lond). 2020 Jun.
Free article

Abstract

A child with pre-B acute lymphoblastic leukaemia (ALL) developed fatal encephalitis associated with human coronavirus OC43 (HCoV-OC43). During chemotherapy the child had a persistent HCoV-OC43 respiratory infection and later developed progressive encephalitis. Cerebrospinal fluid was negative for pathogens including HCoV-OC43, but a brain biopsy was HCoV-OC43-positive by metagenomic next-generation sequencing.

Keywords: Coronavirus; brain biopsy; encephalitis; next generation sequencing.

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