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Multicenter Study
. 2020 Jun;17(3):708-715.
doi: 10.1111/iwj.13330. Epub 2020 Feb 18.

Surgical site infection following operative treatment of open fracture: Incidence and prognostic risk factors

Qifeng Hu  1 , Yanhui Zhao  2 , Baishan Sun  1 , Wei Qi  1 , Pengju Shi  1
Affiliations
Multicenter Study

Surgical site infection following operative treatment of open fracture: Incidence and prognostic risk factors

Qifeng Hu et al. Int Wound J. 2020 Jun.

Retraction in

Abstract

Considering the high incidence of postoperative complications of open fracture, management of this injury is an intractable challenge for orthopaedist, and surgical site infection (SSI) is the devastate one. Screening for high-risk patients and target them with appropriate interventions is important in clinical practice. The aim of this study was to identify modifiable factors that were associated with SSI following operative treatment of open fractures. This retrospective, multicentre study was conducted at three hospitals. A total of 2692 patients with complete data were recruited between June 2015 and July 2018. Demographic characteristics, operation relative variables, additional comorbidities, and biochemical indexes were extracted and analysed. Receiver operating characteristic analysis was performed to detect the optimum cut-off value for some variables. Univariate and multivariate logistic analysis models were performed, respectively, to identify the independent risk factors of SSI. The overall incidence of SSI was 18.6%, with 17.0% and 1.6% for superficial and deep infection, respectively. Results of univariate and multivariate analyses showed the following: fracture type, surgical duration > 122 minutes, anaesthesia time > 130 minutes, intraoperative body temperature < 36.4°C, blood glucose (GLU) > 100 mg/dL, blood platelet (PLT) < 288 × 109 , and white blood cells (WBC) > 9.4 × 109 were independent risk factors of postoperative wound infection following operative treatment of open fractures. Six modifiable factors such as surgical duration > 122 minutes, anaesthesia time > 130 minutes, intraoperative body temperature < 36.4°C, GLU > 100 mg/dL, PLT < 288 × 109, and WBC > 9.4 × 109 play an important role in the prevention of SSI, and these factors should be optimized perioperatively.

Keywords: haematoma; hyperglycaemia; hypothermia; infection; open fractures.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Cut‐off value of anaesthesia time, RBC, and surgical duration identified by the ROC analysis. RBC, red blood cell; ROC, receiver operating characteristic
See this image and copyright information in PMC

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