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Case Reports
. 2020 Feb 13;9(2):80.
doi: 10.3390/antibiotics9020080.

Genomic Characterization of New Variant of Hydrogen Sulfide (H2S)-Producing Escherichia coli with Multidrug Resistance Properties Carrying the mcr-1 Gene in China †

Silpak Biswas  1 , Mohammed Elbediwi  1   2 , Guimin Gu  3 , Min Yue  1   4
Affiliations
Case Reports

Genomic Characterization of New Variant of Hydrogen Sulfide (H2S)-Producing Escherichia coli with Multidrug Resistance Properties Carrying the mcr-1 Gene in China †

Silpak Biswas et al. Antibiotics (Basel). .

Abstract

Colistin is considered to be a 'last-resort' antimicrobial for the treatment of multidrug-resistant Gram-negative bacterial infections. Identification of Enterobacteriaceae, carrying the transferable colistin resistance gene mcr-1, has recently provoked a global health concern. This report presents the first detection of a hydrogen sulfide (H2S)-producing Escherichia coli variant isolated from a human in China, with multidrug resistance (MDR) properties, including colistin resistance by the mcr-1 gene, which could have great implications for the treatment of human infections.

Keywords: Escherichia coli variant; antibiotic resistance genes; genome analysis; hydrogen sulfide; mcr-1.

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Conflict of interest statement

The authors declare no conflict of interest.

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