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. 2020 Apr 21;64(5):e02420-19.
doi: 10.1128/AAC.02420-19. Print 2020 Apr 21.

Genomic Characterization of Neisseria gonorrhoeae Strains from 2016 U.S. Sentinel Surveillance Displaying Reduced Susceptibility to Azithromycin

Matthew W Schmerer #  1 , A Jeanine Abrams #  2 , Sandra Seby  2   3 , Jesse C Thomas 4th  2   3 , John Cartee  2   3 , Sean Lucking  2   3 , Eshaw Vidyaprakash  2   3 , Cau D Pham  2 , Samera Sharpe  2 , Kevin Pettus  2 , Sancta B St Cyr  2 , Elizabeth A Torrone  2 , Ellen N Kersh  2 ; Antimicrobial-Resistant Neisseria gonorrhoeae Working Group; Kim M Gernert  2 ; Antimicrobial-Resistant Neisseria gonorrhoeae Working Group
Collaborators, Affiliations

Genomic Characterization of Neisseria gonorrhoeae Strains from 2016 U.S. Sentinel Surveillance Displaying Reduced Susceptibility to Azithromycin

Matthew W Schmerer et al. Antimicrob Agents Chemother. .

Abstract

In 2016, the proportion of Neisseria gonorrhoeae isolates with reduced susceptibility to azithromycin rose to 3.6%. A phylogenetic analysis of 334 N. gonorrhoeae isolates collected in 2016 revealed a single, geographically diverse lineage of isolates with MICs of 2 to 16 μg/ml that carried a mosaic-like mtr locus, whereas the majority of isolates with MICs of ≥16 μg/ml appeared sporadically and carried 23S rRNA mutations. Continued molecular surveillance of N. gonorrhoeae isolates will identify new resistance mechanisms.

Keywords: 23S rRNA; Neisseria gonorrhoeae; antimicrobial resistance; azithromycin; mosaic-like mtrR.

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Figures

FIG 1
FIG 1
Maximum-likelihood phylogeny of Neisseria gonorrhoeae isolates collected in 2016, including all available isolates exhibiting AZM MICs of ≥2 μg/ml in GISP (n = 117). Lineage characterized by reduced susceptibility to AZM (2 to16 μg/ml) is highlighted in red (clade A). Rings from inside to outside are BAPS clusters, AZM MIC values, HHS regions, 23S rRNA C2611T, 23S rRNA A2059G, mosaic-like mtrR presence, and mtrR promoter mutations.
See this image and copyright information in PMC

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