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Review
. 2020 Feb 11:10:13.
doi: 10.1186/s13578-020-0380-1. eCollection 2020.

Ubiquitin and ubiquitin-like molecules in DNA double strand break repair

Jia Yu  1 , Bo Qin  1   2   3 , Zhenkun Lou  2
Affiliations
Review

Ubiquitin and ubiquitin-like molecules in DNA double strand break repair

Jia Yu et al. Cell Biosci. .

Abstract

Both environmental and endogenous factors induce various forms of DNA damage. DNA double strand break (DSB) is the most deleterious DNA lesion. The swift initiation of a complexed network of interconnected pathways to repair the DNA lesion is essential for cell survival. In the past years, the roles of ubiquitin and ubiquitin-like proteins in DNA damage response and DNA repair has been explored. These findings help us better understand the complicated mechanism of DSB signaling pathways.

Keywords: DNA damage; DNA repair; Double strand break; Ubiquitin; Ubiquitin-like protein.

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Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

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