Sequencing data of cell-free DNA fragments in living-related liver transplantation for inborn errors of metabolism

Abstract

Graft derived cell-free DNA was recently reported as a non-invasive biomarker to detect graft damage or rejection after liver transplantation. There are a number of methods for quantification of Gcf-DNA, including quantitative-PCR, digital droplet PCR and massively parallel sequencing (next generation sequencing). Here we present the NGS data and fragment size distribution of cell-free DNA in the plasma of patients with inborn errors of metabolism who underwent living-related liver transplantation. For more insights please see Analysis of fragment size distribution of cell-free DNA: a potential noninvasive marker to monitor graft damage in living-related liver transplantation for inborn errors of metabolism. [1].

Keywords: Fragment size; Graft derived cell-free DNA; Inborn errors of metabolism; Living-related liver transplantation.

Fig. 1

Size distribution of cell-free DNA in the plasma of liver transplantation patients with inborn errors of metabolism (IEM) before and after operation. Each line represents the size distribution of cell-free DNA in the plasma at different dates, with d0 and d1-60 indicating pre-operation and 1–60 days post-operation, respectively.