Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

Abstract

Background: In the recent outbreak of novel coronavirus infection in Wuhan, China, significantly abnormal coagulation parameters in severe novel coronavirus pneumonia (NCP) cases were a concern.

Objectives: To describe the coagulation feature of patients with NCP.

Methods: Conventional coagulation results and outcomes of 183 consecutive patients with confirmed NCP in Tongji hospital were retrospectively analyzed.

Results: The overall mortality was 11.5%, the non-survivors revealed significantly higher D-dimer and fibrin degradation product (FDP) levels, longer prothrombin time and activated partial thromboplastin time compared to survivors on admission (P < .05); 71.4% of non-survivors and 0.6% survivors met the criteria of disseminated intravascular coagulation during their hospital stay.

Conclusions: The present study shows that abnormal coagulation results, especially markedly elevated D-dimer and FDP are common in deaths with NCP.

Keywords: D-dimer; coagulation parameter; disseminated intravascular coagulation; fibrin degradation product; novel coronavirus pneumonia.

Figure 1

Dynamic profile of coagulation parameters in patients with novel coronavirus pneumonia (NCP). Timeline charts illustrate the changes of coagulation parameters in 183 patients with NCP (21 non‐survivors and 162 survivors) after admission. The error bars show medians and 25% and 75% percentiles. The horizontal lines show the upper normal limits of prothrombin time, activated partial thromboplastin time, D‐dimer and fibrin degradation product, and the lower normal limits of fibrinogen and antithrombin activity, respectively. ^aP < 0.05 for survivors versus non‐survivors