Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Apr;27(2):87-94.
doi: 10.1097/MED.0000000000000532.

Risk factors for myocardial infarction in very young South Asians

Mohit D Gupta  1 , Puneet Gupta  2 , Girish Mp  1 , Ambuj Roy  3 , Arman Qamar  4
Affiliations
Review

Risk factors for myocardial infarction in very young South Asians

Mohit D Gupta et al. Curr Opin Endocrinol Diabetes Obes. 2020 Apr.

Abstract

Purpose of review: It is only over the last few decades that the impact of coronary artery disease (CAD) in very young South Asian population has been recognized. There has been a tremendous interest in elucidating the causes behind this phenomenon and these efforts have uncovered several mechanisms that might explain the early onset of CAD in this population. The complete risk profile of very young South Asians being affected by premature CAD still remains unknown.

Recent findings: The existing data fail to completely explain the burden of premature occurrence of CAD in South Asians especially in very young individuals. Results from some studies identified nine risk factors, including low consumption of fruits and vegetables, smoking, alcohol, diabetes, psychosocial factors, sedentary lifestyle, abdominal obesity, hypertension and dyslipidemia as the cause of myocardial infarction in 90% of the patients in this population. Recent large genome-wide association studies have discovered the association of several novel genetic loci with CAD in South Asians. Nonetheless, continued scientific efforts are required to further our understanding of the causal risk factors of CAD in South Asians to address the rising burden of CVD in this vulnerable population.

Summary: In this review, we discuss established and emerging risk factors of CAD in this population.

PubMed Disclaimer

References

    1. Newman M. Coronary occlusion in young adults. Lancet 1946; 248:409–411.
    1. Gupta M, Brister S, Verma S. Is South Asian ethnicity an independent cardiovascular risk factor? Can J Cardiol 2006; 22:193–197.
    1. Sharma R, Bhairappa S, Prasad SR, Manjunath CN. Clinical characteristics, angiographic profile and in hospital mortality in acute coronary syndrome patients in South Indian population. Heart India 2014; 2:65–69.
    1. Prabhakaran D, Ajay VS. Coronary heart disease in Indians: implications of the INTERHEART study. Indian J Med Res 2010; 132:561–566.
    1. Xavier D, Pais P, Devereaux PJ, et al. Treatment and outcomes of acute coronary syndromes in India (CREATE): a prospective analysis of registry data. Lancet 2008; 371:1435–1442.