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Review
. 2020 May;36(3):230-237.
doi: 10.1097/MOG.0000000000000630.

Update on chronic intestinal pseudo-obstruction

Letizia Zenzeri  1 , Renato Tambucci  2   3 , Paolo Quitadamo  4 , Valentina Giorgio  5 , Roberto De Giorgio  6 , Giovanni Di Nardo  7
Affiliations
Review

Update on chronic intestinal pseudo-obstruction

Letizia Zenzeri et al. Curr Opin Gastroenterol. 2020 May.

Abstract

Purpose of review: Chronic intestinal pseudo-obstruction (CIPO) is the most severe and disabling form of gastrointestinal dysmotility characterized by an impairment of coordinated propulsive activity in the gastrointestinal tract mimicking mechanical intestinal obstruction. Over the last few years, major advances have been made in the diagnostic and therapeutic management of this rare disorder.

Recent findings: The present narrative review aims to summarize the current literature about the management of CIPO focusing on significant novelties about definition, epidemiology, diagnosis, and therapeutic options. The most significant advancement is a consensus on classification and dedicated diagnostic criteria for CIPO in children highlighting the distinctive features between adult and pediatric forms of CIPO (hence pediatric intestinal pseudo-obstruction). Despite no single diagnostic test is pathognomonic of CIPO and no recommended drug treatment is advised to improve gastrointestinal motility, recent reports suggest promising results in both diagnostic testing and therapy that might assist the diagnosis and help the management of patients with CIPO.

Summary: The articles referenced in this review will help in optimizing the clinical management of this rare and severe disease in adult population.

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References

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    1. Thapar N, Saliakellis E, Benninga MA, et al. Paediatric intestinal pseudo-obstruction: evidence and consensus-based recommendations from an ESPGHAN-led expert group. J Pediatr Gastroenterol Nutr 2018; 66:991–1019.
    1. Mousa H, Hyman PE, Cocjin J, et al. Long-term outcome of congenital intestinal pseudo-obstruction. Dig Dis Sci 2002; 47:2298–2305.

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