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. 2020 Feb 17;91(1-S):36-42.
doi: 10.23750/abm.v91i1-S.9250.

A new therapeutic approach for the Dry Eye Syndrome in patients with laryngopharyngeal reflux: first data

Alessandra Balestrazzi  1 , Giulio Cesare Passali  2 , Desiderio Passali  3 , Valerio Damiani  4 , Giorgio Ciprandi  5 , Emilio Balestrazzi  6
Affiliations

A new therapeutic approach for the Dry Eye Syndrome in patients with laryngopharyngeal reflux: first data

Alessandra Balestrazzi et al. Acta Biomed. .

Abstract

Laryngopharyngeal reflux (LPR) is a common disorder. Pepsin has been detected also at eye level, this was a starting point for newest theories about LPR impact on Dry Eye Syndrome. The current preliminary study compared two treatments in patients with Dry Eye Syndrome and LPR. Patients were treated with Gastroftal eye drops and Gastroftal tablets or hyaluronic acid eye drops for 3 months. The following parameters were evaluated: Ocular Surface Disease Index (OSDI), OSDI categories, Reflux Symptom Index (RSI), Reflux Finding Score (RFS), Fluorescein Tear Breakup Time (B-TUT), and Schirmer test before and after treatment. On the whole, 21 patients were enrolled: 10 were treated with hyaluronic acid Atlantis (Group A) and 11 with Gastroftal eye drops and tablets (Group B). After treatment, in Group A only OSDI significantly diminished (p=0.029); in Group B there were significant reductions concerning OSDI (p=0.0277), OSDI categories (p=0.0211), RSI (p=0.0172), Schirmer test (p=0.0172), T-BUT (p=0.0265), and RFS (p=0.0205). The current preliminary demonstrated that the combined ocular and systemic therapy with hyaluronic acid, Magnesium alginate, Simethicone, and Camelia sinensis may be considered a promising treatment in patients with Dry Eye Syndrome due to LPR.

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Conflict of interest statement

all the authors, but DV employee of DMG, have no conflict of interest about this matter.

Figures

Figure 1.
Figure 1.
Box-plot concerning medians and interquartile ranges of OSDI values at baseline and after the treatment in Group A and B
Figure 2.
Figure 2.
Box-plot concerning medians and interquartile ranges of OSDI categories values at baseline and after the treatment in Group A and B
Figure 3.
Figure 3.
Box-plot concerning medians and interquartile ranges of RSI values at baseline and after the treatment in Group A and B
Figure 4.
Figure 4.
Box-plot concerning medians and interquartile ranges of RFS values at baseline and after the treatment in Group A and B
Figure 5.
Figure 5.
Box-plot concerning medians and interquartile ranges of T-BUT values at baseline and after the treatment in Group A and B
Figure 6.
Figure 6.
Box-plot concerning medians and interquartile ranges of Schirmer test values at baseline and after the treatment in Group A and B
See this image and copyright information in PMC

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